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Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Proteins (KLRD1)

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Antibodies (256) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLRD1 3824 Q13241
KLRD1 16643 O54707
KLRD1 25110 O35778
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Top Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$968.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,324.67
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Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,324.67
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,324.67
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Yeast Pongo pygmaeus His tag   1 mg Log in to see 56 to 66 Days
$2,324.67
Details

KLRD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1) Interaction Partners

Human Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1) interaction partners

  1. CD94 and NKG2A (show KLRC1 Proteins) polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF (show TNF Proteins) therapy in patients of Caucasian origin.

  2. Coengagement of inhibitory receptors, either KIR2DL1 (show KIR2DL1 Proteins) or CD94-NKG2A (show KLRC1 Proteins), did not inhibit phosphorylation of Stat5 (show STAT5A Proteins) but inhibited selectively phosphorylation of Akt (show AKT1 Proteins) and S6 ribosomal protein (show RPS6 Proteins).

  3. it is not clear if high expression of CD94 on peripheral blood NK cells is related to abnormal activity of endometrial NK cells.

  4. Data indicate that NKG2 receptor NKG2E (show KLRC3 Proteins) was capable of associating with CD94 and DAP12 (show TYROBP Proteins) but that the complex was retained intracellularly at the endoplasmic reticulum.

  5. Balance between activating NKG2D (show KLRK1 Proteins), DNAM-1 (show CD226 Proteins), NKp44 (show NCR2 Proteins) and NKp46 (show NCR1 Proteins) and inhibitory CD94/NKG2A (show KLRC1 Proteins) receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  6. Data indicate that the expression of KLRD1 (CD94) and NKG2E (KLRC3 (show KLRC3 Proteins)) was reduced in NK-enriched cells in fulminant type 1 diabetes.

  7. NKG2C (show KLRC2 Proteins) zygosity influences CD94/NKG2C (show KLRC2 Proteins) receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus.

  8. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.

  9. Studies indicate that HLA-E (show HLAE Proteins) interacts with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function.

  10. Results suggested that the low expression level of CD94/NKG2A (show KLRC1 Proteins) upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.

Cow (Bovine) Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1) interaction partners

  1. These findings suggest that the CD94/NKG2A (show KLRC1 Proteins) heterodimers in cattle, in contrast to other species, are binding several different ligands.

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1) interaction partners

  1. Segregation of a spontaneous Klrd1 mutation in DBA (show RPS19 Proteins)/2 mouse substrains

  2. The transmembrane region sequences of CD94 and NKG2 in mouse and rat differ markedly from other mammalian orthologs by the presence of a lysine residue in the transmembrane region.

  3. The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A (show KLRC1 Proteins) during responses to different pathogens in vivo.

  4. expression of CD94 and its associated NKG2A (show KLRC1 Proteins), NKG2C (show KLRC2 Proteins), and NKG2E (show KLRC3 Proteins) subunits is dispensable for NK cell development, education, and many NK cell functions

  5. show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus

  6. Implications of CD94 deficiency and monoallelic NKG2A (show KLRC1 Proteins) expression for natural killer cell development and repertoire formation.

  7. CD94 and NKG2 were both expressed early in NK cell development, sometimes in the absence of NK1.1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors.

  8. Inhibitory receptor CD94 is expressed on mature fetal thymic and adult epidermal TCR Vgamma3+ lymphocytes.

  9. The acquisition of individual receptor gene expressions during various stages of differentiation in culture from embryonic stem cells to NK cells follows a predetermined order, with the order of receptor acquisition being first CD94.

  10. There is no evidence that CD94 inhibits either the lytic function of lymphocytic choriomeningitis virus-specific T cells or their capacity to produce effector cytokines upon peptide stimulation.

Killer Cell Lectin-Like Receptor Subfamily D, Member 1 (KLRD1) Protein Profile

Protein Summary

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with KLRD1

  • killer cell lectin-like receptor subfamily D, member 1 (KLRD1)
  • killer cell lectin-like receptor, subfamily D, member 1 (Klrd1)
  • Cd94 protein
  • CD94-B protein

Protein level used designations for KLRD1

CD94 antigen , KP43 , NK cell receptor , natural killer cells antigen CD94 , killer cell lectin-like receptor family D member 1 , killer cell lectin-like receptor subfamily D member 1 , Killer cell lectin-like receptor subfamily D member 1 , CD94 antigen (located within the rat natural killer gene complex)

GENE ID SPECIES
3824 Homo sapiens
444877 Bos taurus
611360 Canis lupus familiaris
574145 Macaca mulatta
450156 Pan troglodytes
16643 Mus musculus
25110 Rattus norvegicus
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