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The protein encoded by KIRREL3 is a member of the nephrin-like protein family. Additionally we are shipping KIRREL3 Antibodies (37) and KIRREL3 Kits (1) and many more products for this protein.
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KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder.
Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle.
Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported.
Kirrel3 is required for formation of hippocampal mossy fiber filopodia; the structures that give rise to dentate granule-GABA synapses and that regulate feed-forward inhibition of CA3 (show CA3 Proteins) neurons.
Kirrel3 has a role in coalescence of vomeronasal sensory neuron axons into glomeruli and in male-male aggression in a resident-intruder assay
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Results suggest Neph2 is involved in the nucleogenesis of the pontine nucleus through the control of neuronal migration inside the nucleus.
In the adult brain, Neph2 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph2 is seen in dendritic shafts of pyramidal neurons.
Results suggest that Kirrel3 plays a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin (show NPHS1 Proteins).
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
kin of IRRE like 3 (Drosophila)
, kin of IRRE-like protein 3
, kin of irregular chiasm-like protein 3
, nephrin-like 2
, nephrin-like protein 2
, X kin of IRRE like 3
, membrane protein mKirre