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Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Antibodies (102) and Kinase Suppressor of Ras 1 Proteins (7) and many more products for this protein.
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the atypical C1 domain, the CC-SAM (show TTN ELISA Kits) domain is required to target KSR-1 to the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 ELISA Kits) module.
Review discusses the possibility that KSR, a RAF (show ARAF ELISA Kits)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 ELISA Kits) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 ELISA Kits)-like proteins.
Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
propose that phosphorylation of Tyr (show TYR ELISA Kits)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
Data indicate that phosphorylation of BRAF (show BRAF ELISA Kits) by AMPK (show PRKAA1 ELISA Kits) disrupts its association with KSR1.
Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 ELISA Kits)-dependent T cell differentiation.
Ksr1 plays a dispensable role in lipopolysaccharide (LPS (show TLR4 ELISA Kits))-induced ERK (show EPHB2 ELISA Kits) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (show TLR4 ELISA Kits) model.
The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 ELISA Kits) pathway signaling leading to increased Myc (show MYC ELISA Kits)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.
a model whereby MARK2 (show MARK2 ELISA Kits) negatively regulates insulin (show INS ELISA Kits) sensitivity in peripheral tissue through inhibition of KSR1
Genetic disruption of KSR1 results in striking reductions in kit-ligand (show KITLG ELISA Kits)-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.
Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 (show MAPK1/3 ELISA Kits) signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.
Upregulation of KSR1 is associated with Colorectal cancer.
the relative mRNA copy values of KSR1, ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits) in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 (show MAPK1/3 ELISA Kits) pathway in gastric cancer
KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 ELISA Kits)+ BC treated with adjuvant TAM (show CCNA1 ELISA Kits).
KSR1 is coordinately regulated with Notch (show NOTCH1 ELISA Kits) signaling and oxidative phosphorylation in papillary thyroid cancer.
KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 ELISA Kits) abundance and increased BRCA1-BARD1 (show BARD1 ELISA Kits) interaction
Our findings integrate KSR1 into a network involving DBC1 (show DBC1 ELISA Kits) and SIRT1 (show SIRT1 ELISA Kits), which results in the regulation of p53 (show TP53 ELISA Kits) acetylation and its transcriptional activity.
Elevated levels of phosphorylated KSR were detected in the nuclear fractions.
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
, kinase suppressor of Ras85D
, suppressor of Ras1 3-1
, kinase suppressor of Ras 1
, protein Hb