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Kinase Suppressor of Ras 2 Proteins (KSR2)

Location-regulated scaffold connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 2 Antibodies (74) and Kinase Suppressor of Ras 2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KSR2 283455 Q6VAB6
KSR2 333050  
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Top Kinase Suppressor of Ras 2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

KSR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Kinase Suppressor of Ras 2 (KSR2) Interaction Partners

Human Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Proteins))/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization.

  2. Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf (show RAF1 Proteins)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.

  3. study demonstrated that miR (show MLXIP Proteins)-31 upregulated IL-2 (show IL2 Proteins) expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation

  4. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.

  5. KSR (show KSR1 Proteins) interacts with a regulatory Raf (show RAF1 Proteins) molecule in cis (show CISH Proteins) to induce a conformational switch of MEK (show MAP2K1 Proteins), facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Proteins) molecule in trans

  6. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (show BCL11A Proteins) cells.

  7. hKSR-2, a new member of the KSR (show KSR1 Proteins) family, negatively regulates Cot (show MAP3K8 Proteins)-mediated MAP kinase (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) pathway signaling

  8. We find that while hKSR-2 blocks MEKK3 (show MAP3K3 Proteins) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (show MAP3K4 Proteins), TAK1 (show MAP3K7 Proteins), and Ras-Raf (show RAF1 Proteins), suggesting that its effects are selective.

  9. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.

  10. KSR-2 may act as a scaffold protein (show HOMER1 Proteins) similar as KSR-1 (show KSR1 Proteins) to mediate the MAPK (show MAPK1 Proteins) core (RAF (show RAF1 Proteins)-MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins)) signaling but with a distinct RAF (show RAF1 Proteins) isoform specificity; KSR-2 may only mediate the A-RAF (show ARAF Proteins) signaling while KSR-1 (show KSR1 Proteins) transduces signals only from c-RAF (show RAF1 Proteins).

Mouse (Murine) Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Proteins))/ORAI1 (show TMEM132A Proteins) puncta formation, which is correlated with cytoskeleton disorganization.

  2. KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways

  3. The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24

  4. KSR2 regulates AMPK (show PRKAA1 Proteins)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.

  5. The protein phosphatase calcineurin (show PPP3CA Proteins) selectively interacts with KSR2 and KSR2 uniquely contributes to Ca2 (show CA2 Proteins)+-mediated ERK (show EPHB2 Proteins) signaling.

Kinase Suppressor of Ras 2 (KSR2) Protein Profile

Protein Summary

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene names and symbols associated with KSR2

  • kinase suppressor of ras 2 (KSR2)
  • kinase suppressor of ras 2 (Ksr2)

Protein level used designations for KSR2

kinase suppressor of Ras 2

GENE ID SPECIES
283455 Homo sapiens
333050 Mus musculus
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