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KIF11 encodes a motor protein that belongs to the kinesin-like protein family. Additionally we are shipping KIF11 Kits (5) and KIF11 Proteins (4) and many more products for this protein.
Showing 10 out of 123 products:
Fruit Fly (Drosophila melanogaster) Polyclonal KIF11 Primary Antibody for ICC, IF - ABIN152995
Ferenz, Wadsworth: Prophase microtubule arrays undergo flux-like behavior in mammalian cells. in Molecular biology of the cell 2007
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Human Monoclonal KIF11 Primary Antibody for ICC, IF - ABIN256473
Bartoli, Jakovljevic, Woolford, Saunders: Kinesin molecular motor Eg5 functions during polypeptide synthesis. in Molecular biology of the cell 2011
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Human Monoclonal KIF11 Primary Antibody for IF, WB - ABIN968406
Blangy, Lane, dHérin, Harper, Kress, Nigg: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. in Cell 1996
Show all 2 Pubmed References
Human Monoclonal KIF11 Primary Antibody for IF, WB - ABIN968407
Ferhat, Cook, Chauviere, Harper, Kress, Lyons, Baas: Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
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Human Polyclonal KIF11 Primary Antibody for ICC, IF - ABIN4307153
Wissing, De Morrée, Dezentjé, Buijs, De Krijger, Smit, Van Weerden, Gelderblom, van der Pluijm: Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness. in Oncotarget 2014
Human Polyclonal KIF11 Primary Antibody for ICC, IF - ABIN4307152
Kuga, Nie, Kazami, Satoh, Matsushita, Nomura, Maeshima, Nakayama, Tomonaga: Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. in Oncogenesis 2014
Progressive retinal degeneration in KIF11-related retinopathy indicates a role for KIF11 not only in ocular development but also in maintaining retinal morphology and function. The remarkable variability of the ocular phenotype suggests four different types of retinopathy which may overlap.
Among the detected mutations, LRP5 (show LRP5 Antibodies) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP Antibodies) (3/31, 9.7%), FZD4 (show FZD4 Antibodies) (2/31, 6.5%), TSPAN12 (show TSPAN12 Antibodies) (1/31, 3.2%), and KIF11 (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
Data show that the kinesin 5 (Eg5) binding time has less sensitivity on MCF7 as compared to bovine brain microtubules.
mixing of Eg5 and MTs (show TIMM8A Antibodies) produced a range of spatiotemporal dynamics
that Pten (show PTEN Antibodies), through the Dlg1 (show DLG1 Antibodies)-binding ability of its PDZ (show INADL Antibodies)-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
KIF11 is an important regulator of activity in oesophageal and colorectal tumor stem cells.
Levels of phosphorylated Erk1/2 (show MAPK1/3 Antibodies) were lower in KIF11 siRNA-transfected cells than with negative-control siRNA-transfected cells. These results indicate that KIF11 is involved in intestinal mucin (show SLC13A2 Antibodies) phenotype gastric cancer.
Patients with KIF11 mutations show a specific ocular phenotype with variable expressivity and intrafamilial variability. Macular atrophy and dysfunction have not been consistently documented before.
This stuidy demonstrated that overexpression of Eg5 associates with high-grade astrocytic neoplasm.
Data show that kinesin spindle protein Eg5 inhibitor LY2523355 has broad target-mediated anticancer activity in vitro and in vivo.
Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.
Fbxo30 (show FBXO30 Antibodies)-Eg5 interaction as a critical checkpoint in mammopoiesis.
Data show that the STIM1 (show STIM1 Antibodies) Ksp (Eg5)-cre knockout mice produced more urine compared to control.
Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.
Disruption of the in vivo interaction of KIF11 with ZBP1 (show ZBP1 Antibodies) delocalizes beta-actin (show ACTB Antibodies) mRNA and affects cell migration.
These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells.
incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5.
Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG (show PAEP Antibodies), the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA.
These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention.
observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 (show DAZL Antibodies) resulted in end-directed Eg5 movement.
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
TR-interacting protein 5
, kinesin-like protein 1
, kinesin-like protein KIF11
, kinesin-like spindle protein HKSP
, kinesin-related motor protein Eg5
, thyroid receptor-interacting protein 5
, kinesin 11
, kinesin-like 1