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human homolog has microtubule stimulated ATPase activity; binds the human discs large (Dlg) tumor suppressor homolog; may play a role in intracellular transport of Dlg. Additionally we are shipping and many more products for this protein.
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Human Polyclonal KIF13B Primary Antibody for ELISA, WB - ABIN525082
Tarbashevich, Dzementsei, Pieler: A novel function for KIF13B in germ cell migration. in Developmental biology 2011
xKIF13B function is linked to polarized accumulation of PIP3 and directional migration of primordial germ cells in Xenopus embryos.
Findings show that the high-affinity binding of KIF13B to DLG (show DLG4 Antibodies) guanylate kinase (show GUK1 Antibodies) (GK) domain does not require phosphorylation of KIF13B and that DLG (show DLG4 Antibodies) binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS (show PPP1R12A Antibodies)] domain) with high specificity and affinity.
lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration.
KIF13B is an essential molecular motor (show MYO1E Antibodies) required for the trafficking of VEGFR2 (show KDR Antibodies) from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis.
Phosphorylation-independent dual-site binding of the FHA (show CRY2 Antibodies) domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b (show MARK2 Antibodies) to the regulation of axon formation.
These results suggest that, in neurons, the GAKIN-PIP3BP complex transports PIP3 to the neurite ends and regulates neuronal polarity formation.
Binding of the SH3-I3-GUK module of hDlg (show DLG1 Antibodies) to GAKIN activates the microtubule-stimulated ATPase (show DNAH8 Antibodies) activity of GAKIN by approximately 10-fold. We propose: the cargo-mediated regulation of motor activity is a general paradigm for the activation of kinesins.
Kif13b also negatively regulates Dlg1 (show DLG1 Antibodies) stability in oligodendrocytes, in which Dlg1 (show DLG1 Antibodies), in contrast to Schwann cells, enhances AKT (show AKT1 Antibodies) activation and promotes myelination
KIF13B, working as a scaffold, recruits LRP1 (show LRP1 Antibodies) to caveolae.
human homolog has microtubule stimulated ATPase activity; binds the human discs large (Dlg) tumor suppressor homolog; may play a role in intracellular transport of Dlg
kinesin family member 13B
, kinesin 13B
, guanylate kinase associated kinesin
, kinesin-like protein GAKIN
, kinesin-like protein KIF13B
, N-3 kinesin