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Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Additionally we are shipping Kinesin Family Member 20A Antibodies (72) and Kinesin Family Member 20A Proteins (4) and many more products for this protein.
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Report expression of mt2 and smt-B upon cadmium exposure and cold shock in zebrafish (Danio rerio).
Signaling cascade of the NIMA-related kinases (Neks) Nek6 (show NEK6 ELISA Kits), Nek7 (show NEK7 ELISA Kits), and Nek9 (show NEK9 ELISA Kits) is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 (show KIF14 ELISA Kits) to properly coordinate cytokinesis.
KIF20A is overexpressed and may serve as an independent prognostic biomarker in Nasopharyngeal Cancer. Targeting KIF20A reduces migration and invasion of Nasopharyngeal Cancer cells.
elevated KIF20A expression correlates with HPV infection, clinical stage, tumor recurrence, lymphovascular space involvement, pelvic lymph node metastasis, and poor outcome in early-stage cervical squamous cell carcinoma patients.
we identify KIF20A as a direct transcriptional target of FOXM1 (show FOXM1 ELISA Kits), involved in paclitaxel action and resistance
Our results provide insight into the link between regulation of KIF20A-mediated trafficking of IGF2BP3 (show IGF2BP3 ELISA Kits)-containing stress granules and modulation of the motility and invasiveness in pancreatic cancers.
Kif20a expression was upregulated in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine cancer compared with normal pancreas. Kif20a silencing resulted in inhibition of proliferation, motility, and invasion of pancreatic cancer cell lines.
Authors propose that phosphoregulation of MKlp2 by Cdk1/cyclin B1 ensures that activation of MKlp2 kinesin and relocation of the CPC occur at the appropriate time and space for proper mitotic progression and genomic stability.
targeting Aurora B (show AURKB ELISA Kits) to the cell cortex (or the equatorial cortex) by MKlp2 is essential for the maintenance of the ingressing furrow for successful cytokinesis
Primary melanomas that were positive for KIF20A showed a significantly greater thickness than those that were negative, and patients with KIF20A+ melanoma tended to develop recurrence earlier.
Used proteomics to identify the genistein-induced protein alterations in gastric cancer cells and found the silencing of KIF20A inhibited cell viability and induced G2/M arrest,& also increased cancer cell sensitivity to genistein inhibition.
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
kinesin family member 20A
, metallothionein 2
, kinesin-like protein KIF20A-like
, RAB6 interacting, kinesin-like (rabkinesin6)
, kinesin-like protein KIF20A
, mitotic kinesin-like protein 2
, rab6-interacting kinesin-like protein
, kinesin-like protein 174