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KLF1 encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. Additionally we are shipping KLF1 Antibodies (75) and KLF1 Kits (3) and many more products for this protein.
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a broad range of hitherto unrelated human red cell disorders are caused by variants in KLF1, a master regulator of erythropoiesis, which were previously considered to be extremely rare causes of human genetic disease [review]
results suggest that KLF1 directly regulates the beta-globin gene, but probably has less direct impact on expression of the gamma-globin gene in fetal erythroblasts
A KLF1-targeted promoter-reporter assay showed that the two mutations reduce the expression of the HBB (show HBB Proteins), BCL11A (show BCL11A Proteins), and CD44 (show CD44 Proteins) genes involved in erythropoiesis.
erythrocyte lineage enforces exclusivity through upregulation of EKLF and its lineage-specific cytokine receptor (show EBI3 Proteins) (EpoR (show EPOR Proteins)) while inhibiting both FLI-1 (show FLI1 Proteins) and the receptor TpoR (show MPL Proteins) (also known as MPL (show MPL Proteins)) for the opposing megakaryocyte lineage
Studies indicate that Kruppel-like factor 1 (KLF1) mutations have been associated with severe hematologic disorders.
a successful induction of gamma-globin (show HBG1 Proteins) includes a reduction in BCL11A (show BCL11A Proteins), KLF1 and TAL1 (show TAL1 Proteins) expression.
The study identified the DEK (show DEK Proteins) oncoprotein as a critical factor that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a positive effect on EKLF levels.
Here we describe a Japanese patient with mild beta-thalassemia with an intact beta-globin (show HBB Proteins) gene but a new missense mutation of c.947G > A or p.C316Y in the KLF1 gene which is strongly associated with the expression of the beta-globin (show HBB Proteins) gene.
The patient with the p.F182L variant (KLF1: c.544T > C) had noticeably high Hb A2 levels (7.6%), consistent with the phenotypic effect of several previously characterized KLF1 mutations in the same exonic region.
These results indicate that KLF1 plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Proteins) and TAL1 (show TAL1 Proteins) occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping
Point mutations in the erythroid transcription factor, Klf1: one mutation, D11 generates a stop codon in the zinc finger domain and a homozygous null phenotype; another mutation, D45, generates an amino acid transversion (H350R) within a linker between zinc fingers two and three.
Data indicate that PIAS3 (protein inhibitor of activated STAT3 (show PIAS3 Proteins)) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner.
Hemin-induced expression of PlGF (show PGF Proteins) is abolished in EKLF-deficient erythroid cells but rescued by conditional expression of EKLF.
HIRA (show HIRA Proteins) is not only critical for beta-globin (show HBB Proteins) expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1).
KLF1 and KLF2 (show KLF2 Proteins) coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes.
EKLF mRNA has exon skipping only in primary tissues. The splice variant is at a low level in embryonic and adult erythroid cells, and in terminal differentiation. The truncated protein partially encodes a non-erythroid Kruppel-like factor AA sequence.
Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.
EKLF plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell
the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors
Similar to its role at the beta-globin (show HBB Proteins) promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner
This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Kruppel-like factor 1 (erythroid)
, Krueppel-like factor 1
, erythroid Kruppel-like factor
, erythroid krueppel-like transcription factor
, erythroid-specific transcription factor EKLF
, monoclonal antibody A3D8
, erythroid transcription factor
, neonatal anemia