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KLF14 encodes a member of the Kruppel-like family of transcription factors. Additionally we are shipping KLF14 Antibodies (24) and KLF14 Kits (14) and many more products for this protein.
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SNPs at the CETP (show CETP Proteins), HNF4A (show HNF4A Proteins) and KLF14 (show SP6 Proteins) locus are associated with HDL (show HSD11B1 Proteins)-C levels and type 2 diabetes (in female participants).
KLF14 (show SP6 Proteins) plays an important role in increasing glucose uptake and insulin (show INS Proteins) sensitivity by the activation of PI3-kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway in vitro.
KLF14 (show SP6 Proteins) transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exis (show SP6 Proteins)ts an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.
Trans (show SP6 Proteins)duction of HepG2 cells with human KLF14 showed that KLF14 is a regu (show SP6 Proteins)lator of APOA1 expres (show HSD11B1 Proteins)sion.
The risk allele C of rs151290 in KCNQ1 (show KCNQ1 Proteins) and risk allele G of rs972283 in KLF14 (show SP6 Proteins) were both associated with increased risk of T2DM in a global population.
This is the first description of the activity and mechanisms underlying the function of KLF14 (show SP6 Proteins) as an activator protein and novel regulator of lipid signaling.
The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.
we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis (show CISH Proteins)-acting expression quantitative trait locus (eQTL (show EQTN Proteins)) of the maternally expressed transcription factor KLF14 (show SP6 Proteins) acts as a master trans regulator of adipose gene expression
KLF14 (show SP6 Proteins) gene is imprinted, with preferential expression from the maternal allele.
the TGFbeta (show TGFB1 Proteins) pathway activation leads to recruitment of a KLF14 (show SP6 Proteins)-mSin3A-HDAC2 (show HDAC2 Proteins) repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.
KLF14 (show SP6 Proteins) reduction serves as a mechanism leading to centrosome amplification and tumorigenesis. On the other hand, forced expression of KLF14 (show SP6 Proteins) leads to mitotic catastrophe.
KLF14 (show SP6 Proteins) is dysregulated in the liver of 2 dyslipidemia mouse models. KLF14 (show SP6 Proteins) regulates plasma HDL (show HSD11B1 Proteins)-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I (show APOA1 Proteins) production. Hepatic-specific Klf14 (show SP6 Proteins) deletion in mice decreased circulating HDL (show HSD11B1 Proteins)-C levels.
The presence of progesterone induced the gene expression of egr-1 (show EGR1 Proteins) and also KLF14 (show SP6 Proteins), indicating that this steroid channels the signaling pathway into a non-canonical mechanism.
KLF14 (show SP6 Proteins) gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse.
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
BTE-binding protein 5
, Krueppel-like factor 14
, basic transcription element-binding protein 5
, transcription factor BTEB5