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KCNIP2 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Additionally we are shipping KCNIP2 Proteins (8) and many more products for this protein.
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Mammalian Monoclonal KCNIP2 Primary Antibody for ISt, IHC - ABIN1304729
Isensee, Wenzel, Buschow, Weissmann, Kuss, Hucho: Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. in PLoS ONE 2015
Show all 40 Pubmed References
Results identify the KChIP2/miR (show MLXIP Antibodies)-34 axis as a central regulator in developing cardiac electrical dysfunction.
A novel KCNQ1 (show KCNQ1 Antibodies)-G229D mutation identified in a juvenile-onset AF patient altered the IKs activity and kinetics, thereby increasing the arrhythmogenicity to AF.
mutations cause a gainoffunction of KV4.3 (show KCND3 Antibodies)/KChIP2encoded channels by increasing membrane protein expression and slowing channel inactivation.
The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 (show KCND3 Antibodies) N-terminal deletion mutant Delta2-39.
KChIP2 differentially regulates total and cell surface Kv4.2 (show KCND2 Antibodies) protein expression and Kv4 (show KCNC1 Antibodies) current densities.
The I(to) activator NS5806 modified Kv4.3 (show KCND3 Antibodies)/KChIP2 gating in several ways that inhibit current.
The cytoplasmic accessory subunit KChIP2 also assembles with Kv4.2 (show KCND2 Antibodies) to increase peak current, shift V1/2 ~5mV, slow time to peak ~10%, slow inactivation ~100%, and speed recovery from inactivation ~250% without overshoot.
N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 (show KCND3 Antibodies) channel/KCHIP2 complex activities.
Down-regulated atrial KChIP2 and Kv4.3 (show KCND3 Antibodies) mRNA expressions in rheumatic heart disease patients with chronic atrial fibrillation might be one of the molecular bases responsible for the down-regulation of the I(to) current density of AF.
Regulation of Kv4.3 (show KCND3 Antibodies) current by KChIP2 splice variants
the Kv4.2 (show KCND2 Antibodies)/KChIP2 interaction in cardiomyocytes is highly dynamic, with a clear KChIP2 gene dosage effect on Kv4 (show KCNC1 Antibodies) channel surface expression but not on inactivation gating.
The downregulation of repolarizing currents in heart failure is accentuated in KChIP2(-/-) mice.
Real-time RT-PCR and Western blotting revealed that Kv4.2 (show KCND2 Antibodies) expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2 (show SOD2 Antibodies)(+/-)+BSO group (P<0.05).
Development of heart failure is independent of K+ channel (show KCNC4 Antibodies)-interacting protein 2 expression.
KChIP2 is essential for physiologic somatodendritic potassium current modulation and homeostatic stability.
The combined down-regulation of Kv4.2 (show KCND2 Antibodies), Kv1.5 (show KCNA5 Antibodies) and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model.
KChIP2 has a role in mediating regulation of CaV1.2 (show CACNA1C Antibodies)
KChIP2 transcripts were highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum.
KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 (show KCNA5 Antibodies) channels
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.
A-type potassium channel modulatory protein 2
, Kv channel-interacting protein 2
, cardiac voltage-gated potassium channel modulatory subunit
, potassium channel-interacting protein 2
, Kv channel interacting protein 2
, potassium channel auxiliary subunit KCHIP2
, Kv channel-interacting protein