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KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Additionally we are shipping Kv Channel Interacting Protein 3, Calsenilin Antibodies (146) and Kv Channel Interacting Protein 3, Calsenilin Kits (10) and many more products for this protein.
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This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2 (show CA2 Proteins)+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 (show EEF1D Proteins) hand is not capable of binding to Ca(2 (show CA2 Proteins)+).
Our approach yields high confidence ranked target gene maps for TP53 (show TP53 Proteins), DREAM, MMB-FOXM1 (show FOXM1 Proteins) and RB-E2F (show E2F1 Proteins) and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.
downregulation of these genes through the p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins)-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53 (show TP53 Proteins).
Our results support the hypothesis that KChIPs enhances Kv4.2 (show KCND2 Proteins) functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.
GCM1 (show GCM1 Proteins)-directed villous trophoblast differentiation is repressed by DREAM
p53 (show TP53 Proteins) can repress transcription of cell cycle genes through a p21(WAF1/CIP1 (show CDKN1A Proteins))-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.
The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin (show CALM1 PLURAL_@34949@) function.
expression of calsenilin leads to a disruption of presenilin 1 (show PSEN1 Proteins)/gamma-secretase-mediated epsilon-cleavage of N-cadherin (show CDH2 Proteins), which results in the significant accumulation of N-cadherin (show CDH2 Proteins) C-terminal fragment 1
The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130 (show RBL2 Proteins)-DREAM complex.
These findings suggest that calsenilin degradation is primarily mediated by the UPP (show UPP1 Proteins) and that impairment in the UPP (show UPP1 Proteins) may contribute to the involvement of calsenilin in disease-associated neurodegeneration.
Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L (show CTSL1 Proteins) and the monoglyceride lipase (show MGLL Proteins) as two new DREAM transcriptional targets related to pain.
association of PS1 (show PSEN1 Proteins) carboxyl peptide (residues 445-467, HL9 (show DDC Proteins)) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 (show PSEN1 Proteins) and F252 from DREAM.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB (show FOSB Proteins), phosphoacetylated histone H3 (show HIST3H3 Proteins), and dynorphin-B in the striatum
NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein (show GUCA1B Proteins) and the T1 domain of the Kv4.3 (show KCND3 Proteins) channels through reorientation of helix 10 on KChIP3
studies define the critical opposing functions of DREAM and USF1 (show USF1 Proteins) in inhibiting and inducing A20 (show TNFAIP3 Proteins) expression
Expression of DREAM in neuroblastoma (show ARHGEF16 Proteins) cells enhances cisplatin mediated caspase-3 (show CASP3 Proteins) activity.
Restoring CANT1 (show CANT1 Proteins) levels in neuroblastoma (show ARHGEF16 Proteins) clones recovered the phenotype, thus confirming a key role of CANT1 (show CANT1 Proteins), and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c).
zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
A-type potassium channel modulatory protein 3
, DRE-antagonist modulator
, calsenilin, presenilin-binding protein, EF hand transcription factor
, kv channel-interacting protein 3
, potassium channel interacting protein 3
, calsenilin, presenilin binding protein, EF hand transcription factor
, A-type potassium channel modulating protein 3
, calsenilin presenilin-binding protein EF hand transcription factor
, calsenilin, presenilin-binding protein, EF hand transcription fa
, downstream regulatory element-antagonist modulator
, Kv channel interacting protein 3, calsenilin