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KCNIP4 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Additionally we are shipping Kv Channel Interacting Protein 4 Antibodies (43) and many more products for this protein.
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Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2 (show KCND2 Proteins).KChIP4 complex was dependent on the expression level of KChIP4.
genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders.
Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse.
KChIP4a suppresses A-type Kv4 (show KCNC1 Proteins) current via ER retention and enhancement of Kv4 (show KCNC1 Proteins) closed-state inactivation.
The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels.
These data demonstrate that PKA phosphorylation of Kv4.2 (show KCND2 Proteins) plays an important role in the trafficking of Kv4.2 (show KCND2 Proteins) through its specific interaction with KChIP4a.
cloning and investigation of interaction with presenilin 2 (show PSEN2 Proteins) and voltage-gated potassium channel subunit Kv4 (show KCNC1 Proteins)
The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2 (show MUC7 Proteins)+- and Ca2 (show CA2 Proteins)+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure.
Mutation of KCNIP4 is associated with renal cell carcinoma (show MOK Proteins).
CALP and calsenilin (show KCNIP3 Proteins) are involved in the trafficking of Golgi glycosyltransferases.
KChIP4a functions to promote tetrameric assembly and enhance surface expression of Kv4 (show KCNC1 Proteins) channels.
KChIP4 was highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum.
Surface expression of Kv4 (show KCNC1 Proteins) complexes may thus be controlled by an auto-inhibitory domain in the KChIP subunit.
N-terminal binding of Kv4.3 (show KCND3 Proteins) to the core of KChIP4a mobilizes the KChIP4a N terminus, which serves as the slow inactivation gate.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Kv channel interacting protein 4
, Kv channel-interacting protein
, Kv channel-interacting protein 4
, a-type potassium channel modulatory protein 4
, calsenilin-like protein
, potassium channel interacting protein 4
, potassium channel-interacting protein 4
, A-type potassium channel modulatory protein 4