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L-2-Hydroxyglutarate Dehydrogenase Proteins (L2HGDH)

L2HGDH encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Additionally we are shipping L2HGDH Antibodies (32) and L2HGDH Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat L2HGDH L2HGDH 314196  
L2HGDH 79944 Q9H9P8
L2HGDH 217666 Q91YP0
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Top L2HGDH Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,142.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

L2HGDH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for L-2-Hydroxyglutarate Dehydrogenase (L2HGDH) Interaction Partners

Human L-2-Hydroxyglutarate Dehydrogenase (L2HGDH) interaction partners

  1. c.845G>A (p.R282Q) in the exon 7 of the L2HGDH gene is associated with 2-hydroxyglutaric aciduria in Chinese family.

  2. Intragenic single nucleotide length polymorphisms and two extragenic microsatellites flanking the L2HGDH gene confirm the founder effect of c.241A>G mutation in the 14 studied cases.

  3. Report ten novel mutations in the L2HGDH gene in patients with L-2-hydroxyglutaric aciduria from different ethnic backgrounds.

  4. L2HGDH mutation is not associated with glioblastoma.

  5. We did not find evidence for mutations in the genes D2HGDH (show D2HGDH Proteins) and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours

  6. Exonic mutations in the L2HGDH gene in Staffordshire bull terriers have been identified and associated with epilepsy.

  7. we present three novel mutations (Gln197X, Gly211Val and c.540+1 G>A), which increase the present deleterious collection of L2HGDH gene up to 35 mutationsthat we have compiled in this study.

  8. encodes a putative mitochondrial protein (show COX6B2 Proteins) with homology to FAD (show BRCA2 Proteins)-dependent oxidoreductases; a mutant gene is accociated with L-2-hydroxyglutaric aciduria.propose to name the gene duranin

  9. data indicate that l-2-hydroxyglutaric aciduria is due to a deficiency in l-2-hydroxyglutarate dehydrogenase

  10. We successfully treated an adult patient with L-2-hydroxyglutaric aciduria using FAD (show BRCA2 Proteins) and levocarnitine.

Mouse (Murine) L-2-Hydroxyglutarate Dehydrogenase (L2HGDH) interaction partners

  1. Data describe a mouse model of L-2-hydroxyglutaric aciduria where mouse with l2hgdh gene deficiency accumulates toxic levels of L-2-hydroxyglutarate mostly in brain and testis and shows significant brain spongiosis and learning deficit.

L2HGDH Protein Profile

Protein Summary

This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.

Gene names and symbols associated with L2HGDH

  • L-2-hydroxyglutarate dehydrogenase (L2hgdh)
  • L-2-hydroxyglutarate dehydrogenase (L2HGDH)
  • BC016226 protein
  • C14orf160 protein
  • RGD1306250 protein

Protein level used designations for L2HGDH

L-2-hydroxyglutarate dehydrogenase, mitochondrial , 2-hydroxyglutarate dehydrogenase , L-alpha-hydroxyglutarate dehydrogenase , alpha-hydroxyglutarate oxidoreductase , alpha-ketoglutarate reductase , duranin

GENE ID SPECIES
314196 Rattus norvegicus
79944 Homo sapiens
217666 Mus musculus
514230 Bos taurus
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