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LHX3 encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. Additionally we are shipping LHX3 Antibodies (25) and LHX3 Proteins (7) and many more products for this protein.
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investigated the specific mutations in PROP1 (show PROP1 ELISA Kits), POU1F1 (show POU1F1 ELISA Kits), LHX3, and HESX1 (show HESX1 ELISA Kits) genes in patients with combined pituitary hormone (show CGA ELISA Kits) deficiency (CPHD) in Turkey
LHX3 is upregulated in high-grade oligodendroglioma.
The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported.
Data suggest that low serum FSH (show BRD2 ELISA Kits) (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta (show FSHB ELISA Kits) subunit (show POLG ELISA Kits); -211G/T) result from reduced LHX3 binding to FSHB (show FSHB ELISA Kits) promoter and down-regulation of FSHB (show FSHB ELISA Kits) transcription in gonadotrophs.
The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2 (show QSOX2 ELISA Kits), and rs1457595 and rs17032362 in IGF1 (show IGF1 ELISA Kits), with adult height in our study population.
descriprion of pediatric patients with combined pituitary hormone (show CGA ELISA Kits) deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene
This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone (show CGA ELISA Kits) deficiency.
This study establishes ISL1 (show ISL1 ELISA Kits) as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1 (show PITX1 ELISA Kits).
LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone (show CGA ELISA Kits) deficiency with short neck and sensorineural hearing impairment. [review]
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 (show QSOX2 ELISA Kits) and IGF1 (show IGF1 ELISA Kits) as adult height loci.
Lhx3 and Lhx4 (show LHX4 ELISA Kits) have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons
LHX3 LIM homeodomain (show LHX2 ELISA Kits) transcription factor is involved in activation of the FSH beta (show FSHB ELISA Kits)-subunit (show POLG ELISA Kits) gene in the pituitary gonadotrope cell.
Association analysis indicated that the some SNPs studied are associated with the body weight at 6, 12 and 18months of age in Nanyang cattle (P<0.01 or P<0.05), providing evidence that some SNPs in LHX3 gene may be associated with body weight at certain ages.
The isolation and characterization of three polymorphisms of LHX3 are reported.
All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A ELISA Kits) and the Isl1 (show ISL1 ELISA Kits)-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
We discovered that expression of Cdkn1a (show CDKN1A ELISA Kits) is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 (show LHX4 ELISA Kits) mutants.
Lhx3-LIM (show PDLIM5 ELISA Kits) domains play critical roles in transactivation of the Isl1 (show ISL1 ELISA Kits)-Lhx3 complex by not only directing the assembly of the Isl1 (show ISL1 ELISA Kits)-Lhx3 complex but also recruiting coactivators to the complex.
This treatment leads to activation of Lhx3 gene expression.
LHX3 interacts with inhibitor of histone acetyltransferase (show HAT ELISA Kits) complex subunits LANP (show ANP32A ELISA Kits) and TAF (show TAF8 ELISA Kits)-1beta to modulate pituitary gene regulation.
The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.
Data characterized an intramolecular interaction between the LIM (show PDLIM5 ELISA Kits) domains and LIM homeobox 3 (Lhx3)-binding domain in Isl1 (show ISL1 ELISA Kits).
Solution structure of the LIM-homeodomain (show LHX2 ELISA Kits) transcription factor complex Lhx3/Ldb1 (show LDB1 ELISA Kits) and the effects of a pituitary mutation on key Lhx3 interactions.
Isl1 (show ISL1 ELISA Kits)-Lhx3, a LIM (show PDLIM5 ELISA Kits)-complex mimicking fusion, induces a signature of motor neuron transcriptome & suppresses interneuron differentiation programs. An equimolar ratio of Isl1 (show ISL1 ELISA Kits) & Lhx3 & the LIM (show PDLIM5 ELISA Kits) domain of Lhx3 are crucial for this.
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4 (show LHX4 ELISA Kits).Isl2 (show ISL2 ELISA Kits) complex exhibit many similarities with that of Lhx3.Isl1 (show ISL1 ELISA Kits); structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.
lim homeobox 3
, LIM homeobox 3
, LIM homeobox protein 3
, LIM/homeobox protein Lhx3
, LIM/homeodomain protein LHX3
, homeobox protein LIM-3
, LIM homeodomain protein 3
, LIM homeodomain 3 protein b isoform
, LIM homeo box protein 3
, homeobox protein P-LIM