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Required for nuclear and mitochondrial iron-sulfur protein biosynthesis (By similarity). Additionally we are shipping LYR Motif Containing 4 Kits (27) and LYR Motif Containing 4 Antibodies (21) and many more products for this protein.
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Our findings highlight that the ISD11 R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1 (show NFS1 Proteins), and thereby fails to prevent NFS1 (show NFS1 Proteins) aggregation resulting in impairment of the Fe-S cluster biogenesis
Homozygous mutation in LYRM4 was reported in two patients with combined oxidative phosphorylation deficiency.
LYRM4 downregulation may be one of the mechanisms involved in inefficient oxidative phosphorylation and oxidative stress, increasingly recognised as contributors to schizophrenia pathogenesis.
Frataxin (show FXN Proteins) interacts with ISD11 and multiple mitochondrial chaperones.
ISD11 is important in the biogenesis of Fe-S clusters in mammalian cells.
Required for nuclear and mitochondrial iron-sulfur protein biosynthesis (By similarity).
LYR motif-containing protein 4
, LYR motif containing 4
, homolog of yeast Isd11
, mitochondrial matrix Nfs1 interacting protein