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catalyzes the hydrolysis of pyridoxine-5'-beta-D-glucoside to release pyridoxine\; also catalyses the hydrolysis of lactose to D-glucose and D-galactose [RGD, Feb 2006].. Additionally we are shipping Lactase Antibodies (121) and Lactase Kits (10) and many more products for this protein.
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Genetic factors contribute to epigenetic changes occurring with age at the regulatory elements, because lactase-persistence and lactase-nonpersistence DNA haplotypes demonstrated markedly different epigenetic aging.
Lactase gene promoter fragments mediate differential spatial and temporal expression patterns in transgenic mice.
Inactivation of Gata4 (show GATA4 Proteins) had no effect on LPH gene expression, whereas inactivation of Hnf1alpha (show HNF1A Proteins) resulted in a 50% reduction in LPH gene expression during either cytodifferentiation or suckling.
Data found transport defects of the intestinal brush border hydrolases lactase-phlorizin hydrolase (LPH) in galectin-3 (show LGALS3 Proteins)-null mutant mice, showing that it directly interact with galectin-3 (show LGALS3 Proteins) and transit through non-raft-dependent apical transport platforms.
Three allelic variants alter promoter function and upregulate LCT gene expression.
Combination of real-time PCR and sequencing was used to detect multiple clinically relevant genetic variations in the lactase gene in Danish patients with lactose intolerance.
The frequency of -13910*T was significantly higher among the Mennonites when compared to the Euro-Brazilian cohort. Accordingly, Mennonites had a higher prevalence of the lactase persistence genotype
Populations from two medieval sites in Central Poland, Stary Brzesc Kujawski-4 (SBK (show SBK1 Proteins)-4) and Gruczno, represented high level of lactase persistence (LP) as followed by the LCT-13910*T allele's presence (0.86 and 0.82, respectively).
In conclusion, our data indicate that identification of a -13910C/C genotype is likely to predict the presence of lactase nonpersistence, in keeping with prior published studies.
Diversity of lactase persistence in African milk drinkers.
Evidence of selection around the LCT gene among Khoe-speaking groups, and the substantial frequency of the 14010C variant among the Nama is best explained by adaptation to digesting milk.
Report reliabile of the single nucleotide polymorphism of lactase persistence LPH(-13910) C/T from saliva (show RAG1AP1 Proteins) derived DNA.
Genotypes of neolithic human remains indicate that natural selection models satisfy the observed increase in allele frequency in lactase persistence.
catalyzes the hydrolysis of pyridoxine-5'-beta-D-glucoside to release pyridoxine\; also catalyses the hydrolysis of lactose to D-glucose and D-galactose
, lactase phlorizin hydrolase
, pyridoxine-5'-beta-D-glucoside hydrolase
, lactase-phlorizin hydrolase
, lactase, gene 2
, lactase-phlorizin hydrolase-1