Lactate Dehydrogenase A Proteins (LDHA)

The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. Additionally we are shipping Lactate Dehydrogenase A Antibodies (242) and Lactate Dehydrogenase A Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LDHA 3939 P00338
LDHA 16828 P06151
Rat LDHA LDHA 24533 P04642
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Top Lactate Dehydrogenase A Proteins at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Lactate Dehydrogenase A (LDHA) (AA 5-323), (partial) protein (His tag) 50 μg Log in to see 13 to 16 Days
$849.20
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$315.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$286.00
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$460.85
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 20 to 21 Days
$228.80
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details

LDHA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) , ,

Rat (Rattus) ,

Top referenced Lactate Dehydrogenase A Proteins

  1. Human Lactate Dehydrogenase A Protein expressed in Escherichia coli (E. coli) - ABIN666950 : Gosti, Marty, Courvalin, Maunoury, Bornens: Centrosomal proteins and lactate dehydrogenase possess a common epitope in human cell lines. in Proceedings of the National Academy of Sciences of the United States of America 1987 (PubMed)
    Show all 2 references for 666950

  2. Human Lactate Dehydrogenase A Protein expressed in Escherichia coli (E. coli) - ABIN1047311 : Tsujibo, Tiano, Li: Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme. in European journal of biochemistry / FEBS 1985 (PubMed)
    Show all 2 references for 1047311

More Proteins for Lactate Dehydrogenase A (LDHA) Interaction Partners

Horse (Equine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes

Rabbit Lactate Dehydrogenase A (LDHA) interaction partners

  1. Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.

Human Lactate Dehydrogenase A (LDHA) interaction partners

  1. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.

  2. Data indicate that lactate dehydrogenase A (LDHA) is involved in the transcription of histone 2B gene.

  3. LDHA downregulation is involved in the apoptotic effect of diallyl trisulfide in triple-negative breast cancer.

  4. this study shows that low levels of LDH correlate to a better anti-CTLA-4 (show CTLA4 Proteins) immunotherapy response and survival in advanced melanoma patients

  5. alternative isoforms of LDH in cancer cells produce lactic acid, when LDHA is silenced or inhibited

  6. Overexpression of PKM2 and LDH5 associates with key clinicopathological features and unfavourable prognosis in tongue squamous cell carcinoma.

  7. These results suggest LDH-A and/or lactate as common elements at the cross-road between cancer cell metabolism, tumor progression and inflammation

  8. High serum LDH is associated with OS and PFS in patients with urinary system cancer, and it is an effective biomarker of prognosis in patients with urologic cancer.

  9. High serum LDH level is associated with cancer.

  10. The number of in advanced-stage diffuse large B cell lymphoma patients with elevated serum lactate dehydrogenase who achieved complete response (CR) after R-CHOP in the non autologous hematopoietic stem cell transplantation (ASCT) group was higher than that in the ASCT group.

Mouse (Murine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.

  2. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.

  3. lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma (show IFNG Proteins) expression independently of its 3'UTR.

  4. LDHA is a direct target of miR (show MLXIP Proteins)-34a in regulating glucose metabolism and tumor growth in breast cancer.

  5. Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.

  6. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta (show TGFB1 Proteins) to drive the fibrotic process.

  7. High LDH-A expression is associated with metastases in breast tumors.

  8. PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene (show MYC Proteins).

  9. Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer.

  10. Down-regulation of expression of stress-activated genes PKC-alpha (show PKCa Proteins), c-Myc (show MYC Proteins) and LDH-A by alpha-tocopherol in cancerous mice.

Pig (Porcine) Lactate Dehydrogenase A (LDHA) interaction partners

  1. These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3 (show SLC2A3 Proteins), LDHA, and SLC16A1 (show SLC16A1 Proteins), which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.

  2. The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.

  3. Both LDHA and COPB1 (show COPB1 Proteins) were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.

Lactate Dehydrogenase A (LDHA) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene names and symbols associated with Lactate Dehydrogenase A Proteins (LDHA)

  • lactate dehydrogenase A (ldha)
  • lactate dehydrogenase A (ldha-b)
  • lactate dehydrogenase A (LDHA)
  • lactate dehydrogenase A (Ldha)
  • lactate dehydrogenase A (LOC100357659)
  • lactate dehydrogenase A4 (ldha)
  • lactate dehydrogenase B (ldhb-b)
  • GSD11 protein
  • l7R2 protein
  • LDH-A protein
  • ldh-h protein
  • LDH-M protein
  • Ldh1 protein
  • ldha protein
  • ldha-B protein
  • ldha1 protein
  • ldhab protein
  • ldhbb protein
  • LDHC protein
  • Ldhm protein
  • pig19 protein
  • trg-5 protein

Protein level used designations for Lactate Dehydrogenase A Proteins (LDHA)

lactate dehydrogenase A1 , L-lactate dehydrogenase A chain , LDH-A , LDH-M , LDH muscle subunit , lactate dehydrogenase C , lactate dehydrogenase-A , L-lactic acid dehydrogenase , lactate dehydrogenase A , upsilon-crystallin , M(A)-type lactate dehydrogenase , lactate dehydrogenase-M , cell proliferation-inducing gene 19 protein , lactate dehydrogenase M , proliferation-inducing gene 19 , renal carcinoma antigen NY-REN-59 , M-LDH , lactate dehydrogenase 1, A chain , lactate dehydrogenase A4 , lactate dehydrogenase A-like , ldha1

GENE ID SPECIES
394758 Xenopus (Silurana) tropicalis
398121 Xenopus laevis
451063 Pan troglodytes
476882 Canis lupus familiaris
503513 Monodelphis domestica
784938 Bos taurus
791112 Ornithorhynchus anatinus
100057016 Equus caballus
100009107 Oryctolagus cuniculus
3939 Homo sapiens
100713875 Cavia porcellus
16828 Mus musculus
24533 Rattus norvegicus
407245 Sus scrofa
281274 Bos taurus
396221 Gallus gallus
100357659 Oryctolagus cuniculus
100173786 Pongo abelii
30496 Danio rerio
394355 Xenopus laevis
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