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Lamin B Receptor Proteins (LBR)

The protein encoded by LBR belongs to the ERG4/ERG24 family. Additionally we are shipping Lamin B Receptor Antibodies (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LBR 3930 Q14739
LBR 98386 Q3U9G9
Rat LBR LBR 89789 O08984
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Top Lamin B Receptor Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

LBR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Lamin B Receptor (LBR) Interaction Partners

Fruit Fly (Drosophila melanogaster) Lamin B Receptor (LBR) interaction partners

  1. dLBR is not a limiting component of the nuclear architecture in Drosophila cells during the first 2 days of development

Zebrafish Lamin B Receptor (LBR) interaction partners

  1. Data indicate that the LBR of zebrafish and mammals are both required for correct development of embryos.

Xenopus laevis Lamin B Receptor (LBR) interaction partners

  1. LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta (show KPNB1 Proteins) in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis

Human Lamin B Receptor (LBR) interaction partners

  1. Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 (show KPNA1 Proteins) vs. NPI3 - 0.00 vs. 0.00; p = 0.0551).

  2. Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype.

  3. Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation.

  4. LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly

  5. The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C (show LMNA Proteins) during in vitro granulopoiesis induced with retinoic acid.

  6. Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor

  7. LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane.

  8. LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta (show KPNB1 Proteins) in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis

  9. LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum.

  10. results suggest that LMNA (show LMNA Proteins), ZMPSTE24 (show Zmpste24 Proteins), and LBR sequence variations are not major genetic determinants involved in scleroderma pathogenesis

Mouse (Murine) Lamin B Receptor (LBR) interaction partners

  1. These results show a moderate skin differentiation phenotype, which indicates that upregulation of LBR is not the sole contributor to the Hutchinson-Gilford progeria syndrome phenotype.

  2. The N-terminal portion of LBR is probably responsible for the binding to HP1b (show CBX1 Proteins).

  3. Study identified LBR- and lamin-A/C (show LMNA Proteins)-dependent mechanisms tethering heterochromatin to the nuclear envelope. The two tethers are sequentially used during cellular differentiation and development: first the LBR- and then the lamin-A/C (show LMNA Proteins)-dependent tether.

  4. LBR deficiency affects not only nuclear architecture but also proliferation, cell viability, and gene expression of hematopoietic cells

  5. sterol Delta(14) reductase domain of LBR plays a critical role in cholesterol biosynthesis and that this process is essential to both myeloid cell growth and functional maturation.

  6. Lbr, under transcriptional regulation of C/EBPepsilon (show CEBPE Proteins), is necessary for morphological but not necessarily functional granulocyte maturation.

  7. lamin B receptor, although residing in nuclear membranes, may contribute to cholesterol biosynthesis in Tm7sf2 (show TM7SF2 Proteins)((-/-)) mice

Lamin B Receptor (LBR) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Gene names and symbols associated with Lamin B Receptor Proteins (LBR)

  • lamin B receptor (LBR)
  • Lamin B receptor (LBR)
  • lamin B receptor (lbr)
  • lamin B receptor (lbr-A)
  • lamin B receptor (Lbr)
  • AI505894 protein
  • CG17952 protein
  • DHCR14B protein
  • dLBR protein
  • Dmel\\CG17952 protein
  • ic protein
  • LBR protein
  • lbr-A protein
  • LMN2R protein
  • Nbp60 protein
  • p58 gene protein
  • PHA protein
  • sb:cb406 protein
  • TDRD18 protein
  • wu:fb75h08 protein
  • wu:fc47b04 protein
  • wu:fd36b07 protein
  • Xp58 protein
  • zgc:86649 protein

Protein level used designations for Lamin B Receptor Proteins (LBR)

CG17952-PA , CG17952-PB , CG17952-PC , LBR-PA , LBR-PB , LBR-PC , lamin B receptor , lamin-B receptor , lamin-B receptor-like , integral nuclear envelope inner membrane protein , tudor domain containing 18 , ichthyosis , Lamin-B receptor

GENE ID SPECIES
100056997 Equus caballus
37482 Drosophila melanogaster
368360 Danio rerio
378609 Xenopus laevis
457776 Pan troglodytes
490391 Canis lupus familiaris
700801 Macaca mulatta
100145693 Xenopus (Silurana) tropicalis
100415074 Callithrix jacchus
100470463 Ailuropoda melanoleuca
100594061 Nomascus leucogenys
3930 Homo sapiens
98386 Mus musculus
89789 Rattus norvegicus
509348 Bos taurus
396285 Gallus gallus
100174610 Pongo abelii
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