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anti-Laminin, alpha 4 (LAMa4) Antibodies

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Additionally we are shipping LAMa4 Proteins (9) and LAMa4 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LAMa4 3910 Q16363
LAMa4 16775 P97927
LAMa4 309816  
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Top anti-LAMa4 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated EIA, IP, WB 0.1 mg Log in to see 6 to 8 Days
$478.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO/293 cells, using LAMA4 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart tissue, using LAMA4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated IP, IHC, ELISA, WB Reactivity of laminin alpha4 chain specific monoclonal antibody 3H2 on human platelet lysate by Western blotting (reducing, R and nonreducing, NR conditions) and on human embryonic kidney preparation 100 μg Log in to see 7 to 9 Days
$342.00
Details
Human Mouse Un-conjugated IP, ELISA, WB Reactivity of laminin alpha4 chain specific monoclonal antibody 9B8 on human platelet lysate by Western blotting (reducing, R and nonreducing, NR conditions). 100 μg Log in to see 7 to 9 Days
$342.00
Details
Human Mouse Un-conjugated EIA, IHC (fro), IP, WB 0.1 mg Log in to see 6 to 8 Days
$478.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Laminin alpha 4 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Laminin alpha 4 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p) IHC-P Image Laminin alpha 4 antibody [C3], C-term detects Laminin alpha 4 protein at cytoplasm on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. Laminin alpha 4 antibody [C3], C-term , diluted at 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemistry (IHC) analyzes of Laminin alpha-4 antibody in paraffin-embedded human heart tissue. Western blot (WB) analysis of Laminin alpha-4 antibody in extracts from COLO cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

LAMa4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LAMa4 Antibodies

  1. Human Monoclonal LAMa4 Primary Antibody for IP, IHC - ABIN400457 : Kawataki, Yamane, Naganuma, Rousselle, Anduraᄅn, Tryggvason, Patarroyo: Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin. in Experimental cell research 2007 (PubMed)
    Show all 2 references for ABIN400457

  2. Human Monoclonal LAMa4 Primary Antibody for EIA, IP - ABIN781771 : Wondimu, Geberhiwot, Ingerpuu, Juronen, Xie, Lindbom, Doi, Kortesmaa, Thyboll, Tryggvason, Fadeel, Patarroyo: An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. in Blood 2004 (PubMed)

  3. Human Polyclonal LAMa4 Primary Antibody for IF, IHC - ABIN1534454 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003 (PubMed)

More Antibodies against LAMa4 Interaction Partners

Zebrafish Laminin, alpha 4 (LAMa4) interaction partners

  1. Knockdown of Lama4 in zebrafish resulted inthe same kind of cardiac dysfunction & hemorrhages seen in Ilk mutants. There is epistatic regulation between laminin-alpha4 (Lama4), integrin, and Ilk.

Human Laminin, alpha 4 (LAMa4) interaction partners

  1. LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes.

  2. LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) activation.

  3. Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK (show MAPK1 Antibodies) signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia.

  4. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (show MCAM Antibodies)).

  5. These results indicate that mAbs to the laminin a4 globular domain are able to inhibit tumor cell adhesion and migration on laminins 411 and 421, and that alpha6beta1 integrin and MCAM (show MCAM Antibodies) bind a4-laminins at very close sites on the globular domain

  6. laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 (show SDC2 Antibodies) and/or -4.

  7. alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma (show TSC2 Antibodies) cells in vivo.

  8. 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure.

  9. LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression.

  10. Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 (show LAMA5 Antibodies) and fibronectin (show FN1 Antibodies), suggesting that tumor cells could utilize laminin-411 in their invasive behavior

Mouse (Murine) Laminin, alpha 4 (LAMa4) interaction partners

  1. Failure of laminin alpha4-mediated down-regulation of PDGF (show PDGFA Antibodies) activity contributes to the progressive renal lesions in this animal model.

  2. biological functions of the laminin alpha 4 chain G domain and screening of active sites

  3. The activity of a cyclic peptide from a region of laminin alpha 4 on the connecting loop between the E and F strands is highly conformation-dependent, suggesting that the E-F loop structure is crucial for its biological activity.

  4. These results suggest that the cryptic alpha4 LG4-5 fragment derived from the laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of FGF-2 (show FGF2 Antibodies) through syndecans.

LAMa4 Antigen Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with LAMa4

  • laminin, alpha 4 (LAMA4) antibody
  • laminin, alpha 4 (lama4) antibody
  • laminin, alpha 4 (Lama4) antibody
  • CMD1JJ antibody
  • LAMA3 antibody
  • LAMA4*-1 antibody
  • RGD1560062 antibody
  • si:busm1-189a20.2 antibody
  • si:dkey-119m7.3 antibody

Protein level used designations for LAMa4

laminin, alpha 4 , laminin subunit alpha-4 , laminin subunit alpha-4-like , laminin alpha 4 chain , laminin [a]4 , laminin-14 subunit alpha , laminin-8 subunit alpha , laminin-9 subunit alpha

GENE ID SPECIES
421749 Gallus gallus
462946 Pan troglodytes
566796 Danio rerio
696685 Macaca mulatta
100066875 Equus caballus
100154581 Sus scrofa
100228260 Taeniopygia guttata
100352418 Oryctolagus cuniculus
100396274 Callithrix jacchus
100587786 Nomascus leucogenys
3910 Homo sapiens
16775 Mus musculus
309816 Rattus norvegicus
475034 Canis lupus familiaris
529670 Bos taurus
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