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BAT3 was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. Additionally we are shipping Large Proline-Rich Protein BAT3 Antibodies (62) and Large Proline-Rich Protein BAT3 Kits (9) and many more products for this protein.
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The observations suggest a mechanism whereby the BAG6 ubiquitin-linked domain provides a platform for discriminating substrates with shorter hydrophobicity stretches as a signal for defective proteins.
we found BAG6 to be dispensable in antigen processing
Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a (show UBL4A Proteins)).
BAG6 also decreases the EP300 (show EP300 Proteins) dependent-acetylation of ATG5 (show ATG5 Proteins), ATG7 (show ATG7 Proteins), and LC3 (show MAP1LC3A Proteins)-I, posttranslational modifications that inhibit autophagy.
BAT3 tightly controls autophagy by modulating p300 (show NOTCH1 Proteins) intracellular localization, affecting the accessibility of p300 (show NOTCH1 Proteins) to its substrates, p53 (show TP53 Proteins) and ATG7 (show ATG7 Proteins).
Mycobacterium tuberculosis-derived protein ESAT-6 (Rv3875) induced transient increase in the expression and release of BAT3 in macrophages.
Bat3 interacts with the nuclear phosphatase small C-terminal domain phosphatase (SCP) 2 (show CRISP3 Proteins), which terminates BMP signaling by dephosphorylating Smad1 (show SMAD1 Proteins)/5/8.
Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation
Scythe regulates apoptosis-inducing factor (show AIFM1 Proteins) stability during endoplasmic reticulum stress-induced apoptosis
Bat3 is identified as a critical regulator of Hsp70-2 (show HSPA2 Proteins) in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility.
BAG6 co-localizes with HSPA2 (show HSPA2 Proteins) in huinan testicular germ cells and epididymal spermatozoa, moving from the equator to the anterior head during capacitation and stably interacting with HSPA2 (show HSPA2 Proteins). In zona pellucida binding defect infertility, BAG6 is lacking.
VNTR in the coding region of the FAM46A gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP are associated with susceptibility to tuberculosis
BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans.
The BAT2/BAT3 polymorphisms and specifically the A/C haplotype may represent a novel immunogenetic factor associated with graft rejection in patients undergoing allo-HSCT.
Data show that molecular chaperone (show HSP90AA1 Proteins) BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A (show UBL4A Proteins) UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA (show SGTA Proteins) protein (SGTA_NT).
This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.
Both TRC35 (show C7orf20 Proteins) and Ubl4A (show UBL4A Proteins) have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
Exogenous BAG6 perturbs the function of the BAG6 complex at a stage subsequent to substrate recognition and polyubiquitylation, most likely the BAG6-dependent delivery of OpD (show FLNA Proteins) to the proteasome.
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
BAG family molecular chaperone regulator 6
, HLA-B-associated transcript 3
, large proline-rich protein BAG6
, large proline-rich protein BAT3
, protein Scythe
, HLA-B associated transcript 3
, HLA-B associated transcript-3
, protein G3
, Large proline-rich protein BAT3