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Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) Proteins (LRAT)

The protein encoded by LRAT is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Additionally we are shipping LRAT Antibodies (66) and LRAT Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LRAT 9227 O95237
LRAT 79235 Q9JI60
LRAT 64047 Q9JI61
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Top LRAT Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,467.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,467.67
Details

LRAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) Interaction Partners

Human Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens.

  2. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells.

  3. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family

  4. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis

  5. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1 (show RBP1 Proteins), that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.

  6. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation.

  7. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens.

  8. Data show that acyl-modified forms of HRAS (show HRAS Proteins)-like tumor suppressors HRASLS2 (show HRASLS2 Proteins) and HRASLS3 (show PLA2G16 Proteins) mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.

  9. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy (show MERTK Proteins).

  10. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis (show CISH Proteins) retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions.

Cow (Bovine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

  2. LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 (show RPE65 Proteins) with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

Mouse (Murine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. examined LRAT regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs

  2. LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma

  3. Mislocalized M-opsin was degraded whereas mislocalized S-opsin (show OPN1SW Proteins) accumulated in Lrat(-/-) cones before the onset of massive ventral/central cone degeneration.

  4. Studies provide mechanistic insights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LRAT as a critical component of this process.

  5. Lrat KO mice exhibited increased levels of retinoic acid-responsive genes, including p21.

  6. Analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine (show SGMS2 Proteins) substrates. The addition of an acyl chain occurs at the Cys (show DNAJC5 Proteins)(161) residue, indicating formation of a thioester intermediate.

  7. FATP1 inhibits 11-cis (show CISH Proteins) retinol formation via interaction with the visual cycle retinoid isomerase RPE65 (show RPE65 Proteins) and lecithin:retinol acyltransferase

  8. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

  9. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

  10. LRAT has a role in retinoid absorption and storage

LRAT Protein Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Gene names and symbols associated with LRAT

  • lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (LRAT)
  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (Lrat)
  • 1300010A18Rik protein
  • AI449251 protein
  • LCA14 protein

Protein level used designations for LRAT

lecithin retinol acyltransferase , phosphatidylcholine--retinol O-acyltransferase , phosphatidylcholine-retinol-O-acyltransferase , lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

GENE ID SPECIES
9227 Homo sapiens
281285 Bos taurus
79235 Mus musculus
64047 Rattus norvegicus
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