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May block the elongation and depolymerization of the actin filaments at the pointed end (By similarity).. Additionally we are shipping Leiomodin 2 Proteins (3) and many more products for this protein.
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Human Polyclonal LMOD2 Primary Antibody for IHC (p), WB - ABIN654322
Tian, Ding, You, Li, Liu, Wu, Sun, Xu: Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy. in Disease models & mechanisms 2015
Crystal Structure of Leiomodin 2 in Complex with Actin
The mutation reduced binding affinity for both Lmod2 and Tmod1 (show TMOD1 Antibodies). The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 (show TMOD1 Antibodies) provides a molecular rationale for the development of familial dilated cardiomyopathies .
The C-terminal extension of Lmod2 and C terminal of Tmod1 (show TMOD1 Antibodies) are sufficient to produce a filament nucleator.
Complementary functional studies suggest that the binding of Lmod2 stimulates ATP hydrolysis and accelerates actin nucleation and polymerization.
study describes an actin-binding protein (show KPTN Antibodies), leiomodin, that acted as a strong filament nucleator in muscle cells
Data indicate that leiomodin 2 protein(Lmod2) functions to elongate actin filaments in the heart.
May block the elongation and depolymerization of the actin filaments at the pointed end (By similarity).