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Leprecan Like Protein 1 (LEPREL1) ELISA Kits

LEPREL1 encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. Additionally we are shipping LEPREL1 Antibodies (15) and LEPREL1 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse LEPREL1 LEPREL1 210530 Q8CG71
Anti-Rat LEPREL1 LEPREL1 288016 Q4KLM6
LEPREL1 55214 Q8IVL5
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Top LEPREL1 ELISA Kits at antibodies-online.com

Showing 1 out of 4 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.063 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details

More ELISA Kits for LEPREL1 Interaction Partners

Mouse (Murine) Leprecan Like Protein 1 (LEPREL1) interaction partners

  1. Altered collagen prolyl 3-hydroxylation is caused by loss of P3H2.

  2. prolyl 3-hydroxylation of type IV collagen (show COL4 ELISA Kits) by P3H2 has an important function preventing maternal platelet aggregation in response to the early developing embryo

  3. P3H2 is responsible for the hydroxylation of collagen IV (show COL4 ELISA Kits), which has the highest 3-hydroxyproline content of all collagens. It is thus possible that P3H2 mutations may lead to a disease with changes in basement membranes.

  4. Study found that all 3 mouse Leprecan (show LEPRE1 ELISA Kits) genes Lepre1 (show LEPRE1 ELISA Kits), leprel1 and leprel2 (show LEPREL2 ELISA Kits) are expressed in the notochord; additionally, they are expressed in dorsal root ganglia, limb buds, branchial arches, and developing kidneys.

  5. This report characterizes expression of the P3H1 (show LEPRE1 ELISA Kits), P3H2 and P3H3 (show LEPREL2 ELISA Kits) genes in embryonic and adult mice.

Human Leprecan Like Protein 1 (LEPREL1) interaction partners

  1. Recessive LEPREL1 mutations should be recognized as part of the differential diagnosis of lens subluxation.

  2. LEPREL1 plays an important role in eye development and homozygous loss-of-function mutation of this gene can cause severely high myopia and early-onset cataract.

  3. mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.

  4. High myopia is caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.

  5. P3H2 has preferred substrate sequences among the classes of 3Hyp sites in clade A collagen chains

  6. P3H2 is responsible for the hydroxylation of collagen IV (show COL4 ELISA Kits), which has the highest 3-hydroxyproline content of all collagens. It is thus possible that P3H2 mutations may lead to a disease with changes in basement membranes.

  7. The restriction of silencing in P3H2 to breast carcinomas, and its association with oestrogen-receptor-positive cases, suggests that P3H2 may be a breast-cancer-specific tumour suppressor.

LEPREL1 Antigen Profile

Antigen Summary

This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with LEPREL1

  • leprecan-like 1 (Leprel1) antibody
  • leprecan-like 1 (LEPREL1) antibody
  • 4832416N06 antibody
  • AW553532 antibody
  • MCVD antibody
  • MLAT4 antibody
  • P3H2 antibody

Protein level used designations for LEPREL1

leprecan-like protein 1 , myxoid liposarcoma associated protein 4 , prolyl 3-hydroxylase 2 , myxoid liposarcoma-associated protein 4 , prolyl 3-hydroxylase 3

GENE ID SPECIES
210530 Mus musculus
288016 Rattus norvegicus
55214 Homo sapiens
414143 Gallus gallus
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