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Leucine Carboxyl Methyltransferase 1 Proteins (LCMT1)

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Leucine Carboxyl Methyltransferase 1 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LCMT1 51451 Q9UIC8
Mouse LCMT1 LCMT1 30949  
LCMT1 361643 Q6P4Z6
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Top Leucine Carboxyl Methyltransferase 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LCMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Top referenced Leucine Carboxyl Methyltransferase 1 Proteins

  1. Human LCMT1 Protein expressed in Escherichia coli (E. coli) - ABIN667640 : De Baere, Derua, Janssens, Van Hoof, Waelkens, Merlevede, Goris: Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. in Biochemistry 2000 (PubMed)
    Show all 2 references for ABIN667640

More Proteins for Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaction Partners

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. LCMT1-PME-1 (show PPME1 Proteins) methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. alterations in the membrane localization of PP2A (show PPP2R4 Proteins) and Tau following down-regulation of LCMT1 may lead to PP2A (show PPP2R4 Proteins) and Tau dysfunction in AD.

  3. Data indicate that PP2A (show PPP2R4 Proteins) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Proteins) modulators, consisting of alpha4, PTPA (show PPP2R4 Proteins), LCMT1, PME-1 (show PPME1 Proteins) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  4. GSK-3beta can inhibit PP2A (show PPP2R4 Proteins) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 (show PPME1 Proteins) and inhibition of PPMT1

  5. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A (show PPP2R4 Proteins) stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A (show PPP2R4 Proteins)

  6. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet (show MAT1A Proteins)) has been solved to a resolution of 2 A.

  7. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) interaction partners

  1. In LCMT1 deficiency enzyme activity and methylation of PP2A (show PPP2R2B Proteins) are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A (show PPP2R2B Proteins) methyltransferase.

  2. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  3. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) Protein Profile

Protein Summary

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Gene names and symbols associated with LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1)
  • leucine carboxyl methyltransferase 1 (lcmt1)
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074)
  • leucine carboxyl methyltransferase 1 (PTRG_02142)
  • leucine carboxyl methyltransferase 1 (MCYG_00360)
  • leucine carboxyl methyltransferase 1 (AOR_1_842194)
  • leucine carboxyl methyltransferase 1 (Tsp_08223)
  • leucine carboxyl methyltransferase 1 (Lcmt1)
  • AL033290 protein
  • Lcmt protein
  • LCMT-1 protein
  • MGC114784 protein
  • PPMT1 protein
  • zgc:101094 protein

Protein level used designations for LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPECIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
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