Leucine Rich Repeat Containing 8 Family, Member A Proteins (LRRC8A)

LRRC8A encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. Additionally we are shipping LRRC8A Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LRRC8A 56262 Q8IWT6
Rat LRRC8A LRRC8A 311846 Q4V8I7
LRRC8A 241296 Q80WG5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top LRRC8A Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

LRRC8A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) Interaction Partners

Human Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS Proteins) sensitivity and glucose tolerance.

  2. LRRC8 channels transport the neurotransmitters glutamate (show GRIN1 Proteins), aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine.

  3. It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 (show SLC31A1 Proteins) and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A (show ATP7A Proteins), ATP7B (show ATP7B Proteins)), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes.

  4. LRRC8A is an essential regulator of cisplatin induced p53 (show TP53 Proteins) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2 (show MDM2 Proteins), as well as activation of caspase-9 (show CASP9 Proteins) and -3 in tumor cell lines.

  5. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  6. These data suggest that LRRC8A is associated with the deceleration mechanism of Volume-sensitive outwardly rectifying anion channel inactivation, while none of LRRC8 members is related to the acceleration mechanism.

  7. Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.

  8. Genomic disruption of LRRC8A ablated volume-regulated anion channel (VRAC) currents. Cells with disruption of all five LRRC8 genes required LRRC8A cotransfection with other LRRC8 isoforms to reconstitute VRAC currents.

  9. LRRC8 is required for B cell development.

  10. identified four genes, named TA-LRRP, AD158 (show LRRC8C Proteins), LRRC5, and FLJ23420, as unknown LRRC8-like genes

Mouse (Murine) Leucine Rich Repeat Containing 8 Family, Member A (LRRC8A) interaction partners

  1. Identify SWELL1 as a cell-autonomous sensor of adipocyte size that regulates adipocyte growth, insulin (show INS Proteins) sensitivity and glucose tolerance.

  2. volume-sensitive outwardly rectifying currents were found to be largely reduced by siRNA against LRRC8A

  3. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

LRRC8A Protein Profile

Protein Summary

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene names and symbols associated with LRRC8A

  • leucine rich repeat containing 8 family, member A (lrrc8a)
  • leucine rich repeat containing 8 family, member A (LRRC8A)
  • leucine rich repeat containing 8 family, member A (Lrrc8a)
  • leucine rich repeat containing 8A (Lrrc8a)
  • AGM5 protein
  • LLRC8A protein
  • Lrrc8 protein
  • mKIAA1437 protein
  • wu:fb18g12 protein
  • wu:fi21b10 protein

Protein level used designations for LRRC8A

leucine-rich repeat-containing protein 8A , leucine rich repeat containing 8A , leucine-rich repeat-containing 8

GENE ID SPECIES
327642 Danio rerio
494672 Xenopus laevis
417201 Gallus gallus
56262 Homo sapiens
491309 Canis lupus familiaris
505605 Bos taurus
311846 Rattus norvegicus
241296 Mus musculus
Selected quality suppliers for LRRC8A Proteins (LRRC8A)
Did you look for something else?