anti-Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) Antibodies

LRSAM1 encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Additionally we are shipping LRSAM1 Proteins (6) and LRSAM1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LRSAM1 90678 Q6UWE0
LRSAM1 227738 Q80ZI6
LRSAM1    
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Top anti-LRSAM1 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacted with LRSAM1 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and   followed by DAB staining. Western blot analysis of LRSAM1 Antibody 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: LRSAM1 Antibody [NBP1-82017] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Mouse Rabbit Un-conjugated IHC (p), WB LRSAM1 Antibody (N-term) (ABIN656897) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using LRSAM1 antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

LRSAM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LRSAM1 Antibodies

  1. Human Polyclonal LRSAM1 Primary Antibody for IHC, IHC (p) - ABIN4331719 : Bogdanik, Sleigh, Tian, Samuels, Bedard, Seburn, Burgess: Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease. in Disease models & mechanisms 2013 (PubMed)

More Antibodies against LRSAM1 Interaction Partners

Human Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated.

  2. findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery.

  3. findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1.

  4. LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination.

  5. Plant homeodomain finger protein 23 negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

  6. disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1

  7. Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance.

  8. Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination.

  9. homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy

  10. LRSAM1 as a component of the antibacterial autophagic response.

Mouse (Murine) Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1) interaction partners

  1. TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.

  2. Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised.

LRSAM1 Antigen Profile

Protein Summary

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with LRSAM1

  • leucine rich repeat and sterile alpha motif containing 1 (LRSAM1) antibody
  • leucine rich repeat and sterile alpha motif containing 1 (Lrsam1) antibody
  • CMT2P antibody
  • RIFLE antibody
  • TAL antibody

Protein level used designations for LRSAM1

E3 ubiquitin-protein ligase LRSAM1 , Tsg101-associated ligase , leucine-rich repeat and sterile alpha motif-containing protein 1 , tsg101-associated ligase

GENE ID SPECIES
90678 Homo sapiens
227738 Mus musculus
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