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anti-Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) Antibodies

LETM1 encodes a protein that is localized to the inner mitochondrial membrane. Additionally we are shipping LETM1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LETM1 3954 O95202
LETM1 56384 Q9Z2I0
LETM1 305457 Q5XIN6
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Top anti-LETM1 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-LETM1 Antibody Titration: 5.0ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to LETM1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to LETM1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.99 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB LETM1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the LETM1 antibody detected the LETM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to LETM1 on HeLa cell (antibody concentration 10 µg/mL). LETM1 monoclonal antibody (M03), clone 6F7 Western Blot analysis of LETM1 expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB LETM1 antibody used at 5 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details

LETM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LETM1 Antibodies

  1. Human Monoclonal LETM1 Primary Antibody for IF, IHC (p) - ABIN561659 : Dimmer, Navoni, Casarin, Trevisson, Endele, Winterpacht, Salviati, Scorrano: LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability. in Human molecular genetics 2008 (PubMed)
    Show all 6 references for ABIN561659

  2. Human Polyclonal LETM1 Primary Antibody for ELISA, WB - ABIN517469 : Mallilankaraman, Cárdenas, Doonan, Chandramoorthy, Irrinki, Golenár, Csordás, Madireddi, Yang, Müller, Miller, Kolesar, Molgó, Kaufman, Hajnóczky, Foskett, Madesh: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. in Nature cell biology 2012 (PubMed)

More Antibodies against LETM1 Interaction Partners

Human Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. LETM1 plays an important role in the progression of breast cancer

  2. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.

  3. LETM1 plays an important role in the progression of head and neck squamous cell carcinoma.

  4. Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB (show MT-CYB Antibodies) expression, which is associated with susceptibility to seizures.

  5. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2 (show CA2 Antibodies)+) transport and bioenergetics

  6. These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level.

  7. Haploinsufficiency of WHSC1 (show WHSC1 Antibodies) and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype.

  8. NCLX (show SLC24A6 Antibodies), but not LETM1, mediates Ca(2 (show CA2 Antibodies)+) extrusion from mitochondria. By controlling the duration of matrix Ca(2 (show CA2 Antibodies)+) elevations, NCLX (show SLC24A6 Antibodies) contributes to the regulation of NAD(P)H (show NQO1 Antibodies) production and to the conversion of Ca(2 (show CA2 Antibodies)+) signals into redox changes.

  9. Functional properties of Letm1 described in study are remarkably similar to those of the H(+)-dependent Ca(2 (show CA2 Antibodies)+) transport mechanism identified in intact mitochondria.

  10. Data indicate that loss of Letm1 contributes to the path (show CA2 Antibodies)ology of Wolf-Hirschhorn syndrome and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations.

Mouse (Murine) Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 (LETM1) interaction partners

  1. Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2 (show CA2 Antibodies)+) transport and bioenergetics

  2. Data indicate that cellular Letm1 knockdown reduced Ca(2 (show CA2 Antibodies)+)mito uptake, H(+)mito extrusion and impaired mitochondrial ATP generation capacity.

LETM1 Antigen Profile

Protein Summary

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.

Gene names and symbols associated with LETM1

  • leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (letm1) antibody
  • leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) antibody
  • letm1 antibody
  • MGC145623 antibody
  • wu:fc31h08 antibody
  • wu:fc58h01 antibody
  • zgc:109969 antibody

Protein level used designations for LETM1

leucine zipper-EF-hand containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial , fc31h08 , fc58h01 , let-m1 , leucine zipper-EF-hand-containing transmembrane protein 1 , Leucine zipper-EF-hand-containing transmembrane protein 1 , LETM1 and EF-hand domain-containing protein 1, mitochondrial-like , Mdm38 homolog

GENE ID SPECIES
461068 Pan troglodytes
570745 Danio rerio
780254 Xenopus (Silurana) tropicalis
100052731 Equus caballus
100346816 Oryctolagus cuniculus
100408245 Callithrix jacchus
100433508 Pongo abelii
100586576 Nomascus leucogenys
422898 Gallus gallus
3954 Homo sapiens
488807 Canis lupus familiaris
513324 Bos taurus
56384 Mus musculus
305457 Rattus norvegicus
Selected quality suppliers for anti-LETM1 (LETM1) Antibodies
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