Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 Proteins (LGR4)

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Antibodies (90) and LGR4 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LGR4 55366 Q9BXB1
LGR4 107515 A2ARI4
Rat LGR4 LGR4 286994 Q9Z2H4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top LGR4 Proteins at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

LGR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) Interaction Partners

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. the host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells.

  2. High LGR4 expression is associated with osteoarthritis.

  3. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation.

  4. LGR4 is another receptor for RANKL (show TNFSF11 Proteins). LGR4 competes with RANK to bind RANKL (show TNFSF11 Proteins) and suppresses canonical RANK signaling during osteoclast differentiation.

  5. The LGR4 A750T variant is correlated with central obesity-related characteristics in young subjects.

  6. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1 (show MAP2K1 Proteins)/ERK1/2 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.

  7. miR (show MLXIP Proteins)-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration and adhesion partly by suppressing LGR4 expression.

  8. Lgr4 activates Jmjd2a/AR signaling pathway to promote interaction AR with PSA promoter, causing reduction of prostate cancer apoptosis and cell cycle arrest.

  9. A mechanistic understanding of RANKL (show TNFSF11 Proteins)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Proteins) signaling in osteoporosis and other diseases

  10. miR (show MLXIP Proteins)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways in the LNCaP-IL-6 (show IL6 Proteins)+ cells.

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. the host protein leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is essential for VSV and VSV-G pseudotyped lentivirus (VSVG-LV) to infect susceptible cells.

  2. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation.

  3. LGR4 is another receptor for RANKL (show TNFSF11 Proteins). LGR4 competes with RANK to bind RANKL (show TNFSF11 Proteins) and suppresses canonical RANK signaling during osteoclast differentiation. Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast number, surface area, and size) and increased bone erosion.

  4. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1 (show MAP2K1 Proteins)/ERK1/2 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.

  5. RSPO (show RSPO1 Proteins)-LGR4/5-ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  6. These date indicate that hydrogen peroxide suppresses Lgr4 expression in osteoblastic cells.

  7. Lgr4 gene is regulated by BMP and is required for BMP effects on osteoblastic differentiation.

  8. Rspo1 (show RSPO1 Proteins) and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling for bone formation.

  9. Study suggests that miR (show MLXIP Proteins)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.

  10. A mechanistic understanding of RANKL (show TNFSF11 Proteins)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Proteins) signaling in osteoporosis and other diseases

LGR4 Protein Profile

Protein Summary

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008

Gene names and symbols associated with LGR4

  • leucine-rich repeat containing G protein-coupled receptor 4 (LGR4)
  • leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4)
  • 9130225G07 protein
  • A330106J01Rik protein
  • A930009A08Rik protein
  • BNMD17 protein
  • Gpr48 protein

Protein level used designations for LGR4

G protein-coupled receptor 48 , leucine-rich repeat-containing G-protein coupled receptor 4 , G protein-coupled receptor GPR48 , G-protein coupled receptor 48

GENE ID SPECIES
55366 Homo sapiens
451088 Pan troglodytes
107515 Mus musculus
286994 Rattus norvegicus
Selected quality suppliers for LGR4 Proteins (LGR4)
Did you look for something else?