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G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Antibodies (78) and LGR4 Kits (15) and many more products for this protein.
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A mechanistic understanding of RANKL (show TNFSF11 Proteins)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Proteins) signaling in osteoporosis and other diseases
miR (show MLXIP Proteins)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways in the LNCaP-IL-6 (show IL6 Proteins)+ cells.
LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.
These findings suggest that aberrant RSPO3 (show RSPO3 Proteins)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Proteins)-deficient lung ADs (show AGPS Proteins).
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
our results suggest a previously unknown Stat3 (show STAT3 Proteins)-LGR4 molecular network, which may control osteosarcoma development and progression
RSPO (show RSPO1 Proteins)-LGR4 not only induces the clearance of RNF43 (show RNF43 Proteins)/ZNRF3 (show ZNRF3 Proteins) to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 Proteins) signaling complex.
Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR (show AGRN Proteins) syndrome
GPR48 overexpression promotes cancer cell proliferation via activation of Wnt (show WNT2 Proteins) signaling.
Lgr4 overexpression promoted glioma cell proliferation through activation of Wnt (show WNT2 Proteins) signaling.
Rspo1 (show RSPO1 Proteins) and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling for bone formation.
Study suggests that miR (show MLXIP Proteins)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.
LGR4 acted as a key receptor for Rspo2 (show RSPO2 Proteins) to promote osteogenesis.
Lgr4 is critical for ovarian somatic cell specialization via the cooperative signaling of Rspo1 (show RSPO1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)
results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging.
The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Proteins)-mediated Lgr4-Wnt (show WNT2 Proteins) signaling during gonadal development.
suggests that Lgr4 might serve as an adaptive regulator between glucose and lipid metabolism in skeletal muscle and reveals a potentially new regulator for a well-established adaptive network
An important role for Lgr4 in motor coordination and cerebellar synaptic plasticity.
formation of polycystic lesions and renal fibrosis induced by Gpr48 deficiency involves the activation of Wnt (show WNT2 Proteins) signaling pathway but not the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008
G protein-coupled receptor 48
, leucine-rich repeat-containing G-protein coupled receptor 4
, G protein-coupled receptor GPR48
, G-protein coupled receptor 48