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Lipase A, Lysosomal Acid, Cholesterol Esterase Proteins (LIPA)

LIPA encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). Additionally we are shipping Lipase A Antibodies (90) and Lipase A Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LIPA 3988 P38571
LIPA 25055  
LIPA 16889 Q9Z0M5
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Top Lipase A Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,039.67
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Please inquire Un-conjugated   10 mg Log in to see 6 Days
$168.54
Details

LIPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)
,

More Proteins for Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA) Interaction Partners

Pig (Porcine) Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA) interaction partners

  1. Cholesterol esterase shows enantioselective inhibition for enantiomers of exo- and endo-2-norbornyl-N-n-butylcarbamates.

Human Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA) interaction partners

  1. These findings suggest a strong association between impaired LAL activity and Non-alcoholic fatty liver disease.

  2. lyso (show LIPF Proteins)somal acid lipase in hepatocytes is a critical metabolic enzyme in controlling neutral lipid metabolism

  3. The observed loss-of-function phenotype in cholesteryl ester storage disease patients with the His295Tyr (H295Y) mutation in the LAL gene might arise from a combination of protein destabilization and the shift to a non-functional soluble aggregate.

  4. Case Report: Mexican sisters with heterozygous mutations in exon 4: c.253C>A and c.294C>G resulting in lysosomal acid lipase deficiency.

  5. To our knowledge, this is the first pediatric case of genetically and biopsy confirmed CESD without hepatomegaly, suggesting that this diagnosis can be easily missed.

  6. the rs1412444 and rs2246833 of the LIPA gene are shared susceptibility polymorphisms for CAD among different ethnicities.

  7. used (1)H magnetic resonance (MR) spectroscopy to characterize the abnormalities in hepatic lipid content and composition in patients with LAL deficiency

  8. The results show that lysosomal acid lipase E8SJM mutation carriers have an alteration in lipid profile with a Polygenic Hypercholesterolemia phenotype.

  9. CESD prevalence in African and Asian populations may require full-gene LIPA sequencing to determine heterozygote frequencies. CESD may be underdiagnosed in the general Caucasian and Hispanic populations.

  10. Mutations in lysosomal acid lipase A result in two phenotypes depending on the extent of lysosomal acid lipase deficiency. [Review]

Mouse (Murine) Lipase A, Lysosomal Acid, Cholesterol Esterase (LIPA) interaction partners

  1. hLAL (show LIPF Proteins) expression reduced tumor-promoting myeloid-derived suppressive cells in the liver of lal(-/-) mice

  2. Results indicate that LAL has a critical role in regulating MDSCs' ability to directly stimulate cancer cell proliferation and overcome immune rejection of cancer metastasis in allogeneic mice through modulation of the mTOR (show FRAP1 Proteins) pathway.

  3. effect the loss of SOAT2 (show SOAT2 Proteins) function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease

  4. Lipolysis of triacylglycerol substrates by LAL is important for M2 macrophage activation, and its inhibition suppresses M2 activation.

  5. LAL regulates endothelial cell function through interaction with myeloid-derived suppressor cells and modulation of the mTOR (show FRAP1 Proteins) pathway, which provide mechanistic basis for targeting MDSCs or mTOR (show FRAP1 Proteins) to rejuvenate EC functions in LAL deficiency-related diseases

  6. These results indicate a crucial role of LAL-regulated mTOR signaling in the production and function of CD11b(+)Ly6G(+) cells.

  7. SR-BI (show SCARB1 Proteins)-delivered HDL (show HSD11B1 Proteins)-CEs are hydrolyzed by hepatic CEH (show EPHX2 Proteins) and utilized for bile acid synthesi

  8. FoxO1 (show FOXO1 Proteins) is upregulated by nutrient restriction (NR) in adipocytes and exerts the transcriptional control of lipid catabolism via the induction of lysosomal acid lipase

  9. analysis of important gene pathways involved in the myeloid lineage cells towards MDSCs using lal-/- mouse model

  10. Transgenic overexpression of CEH (show EPHX2 Proteins) in macrophages polarizes hepatic macrophages (Kupffer cells) to an anti-inflammatory M2 phenotype that attenuates hepatic lipid synthesis and accumulation.

Lipase A (LIPA) Protein Profile

Protein Summary

This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with LIPA

  • lipase A, lysosomal acid, cholesterol esterase (LIPA)
  • lipase A, lysosomal acid, cholesterol esterase (lipa)
  • lipase A, lysosomal acid, cholesterol esterase (Lipa)
  • lysosomal acid lipase A (Lipa)
  • AA960673 protein
  • CESD protein
  • Chole protein
  • Chole2 protein
  • Lal protein
  • Lip-1 protein
  • Lip1 protein
  • LIPA protein

Protein level used designations for LIPA

lipase A, lysosomal acid, cholesterol esterase (Wolman disease) , lysosomal acid lipase/cholesteryl ester hydrolase , lipase A, lysosomal acid, cholesterol esterase , lysosomal acid lipase/cholesteryl ester hydrolase-like , acid cholesteryl ester hydrolase , cholesterol ester hydrolase , cholesteryl esterase , lysosomal acid lipase , sterol esterase , Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25 , lysosomal acid lipase 1 , lysosomal acid lipase A , pancreatic cholesterol esterase , lipase A

GENE ID SPECIES
466150 Pan troglodytes
548564 Xenopus (Silurana) tropicalis
610650 Canis lupus familiaris
734759 Xenopus laevis
100071626 Equus caballus
100125267 Bos taurus
100142668 Sus scrofa
100145859 Ovis aries
100453604 Pongo abelii
100583764 Nomascus leucogenys
3988 Homo sapiens
25055 Rattus norvegicus
16889 Mus musculus
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