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The protein encoded by LPPR5 is a type 2 member of the phosphatidic acid phosphatase (PAP) family.
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A novel human phosphatidic acid phosphatase type 2 isoform cDNAs (PAP2d) from the fetal brain cDNA library was cloned and characterized.
Data indicate that plasticity-related genes 5 (PRG5) expression is involved in proper spine formation.
Data show that PRG5 induces filopodia growth independently of Cdc42 (show CDC42 Antibodies), and that axon collapse and RhoA (show RHOA Antibodies) activation induced by LPA and myelin-associated neurite inhibitor Nogo-A (show RTN4 Antibodies) is attenuated in the presence of PRG5.
The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
phosphatidic acid phosphatase type 2
, phosphatidic acid phosphatase type 2d
, plasticity-related protein 5
, phosphatidic acid phosphatase 2d
, plasticity-related gene 5 protein
, lipid phosphate phosphatase-related protein type 5
, plasticity related gene 5