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Lipoma HMGIC Fusion Partner-Like 5 Proteins (LHFPL5)

LHFPL5 is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Additionally we are shipping LHFPL5 Antibodies (20) and LHFPL5 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LHFPL5 222662 Q8TAF8
LHFPL5 328789 Q4KL25
Rat LHFPL5 LHFPL5 294303 Q5PPI7
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Top LHFPL5 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

LHFPL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Lipoma HMGIC Fusion Partner-Like 5 (LHFPL5) Interaction Partners

Human Lipoma HMGIC Fusion Partner-Like 5 (LHFPL5) interaction partners

  1. LHFPL5 mutation is associated with dysequilibrium syndrome type 2 and sensorineural hearing loss.

  2. Five microsatellites in the 6p21.31e22.3 region and screening of the LHFPL5 gene by DNA heteroduplex analysis revealed a novel mutation (c.89dup) in one out of 129 unrelated Tunisian families with autosomal recessive nonsyndromic hearing loss.

  3. These findings establish the importance of TMHS for normal sound transduction in humans.

  4. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies

  5. The authors present an overview of the LHFP gene family in mouse and humans

Mouse (Murine) Lipoma HMGIC Fusion Partner-Like 5 (LHFPL5) interaction partners

  1. TMHS is an integral component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 (show PCDH15 Proteins) to the transduction channel.

  2. TMHS localizes to the apical membrane of inner ear hair cells during stereocilia formation suggesting a function in hair bundle morphogenesis; a missense mutation underlies deafness in hurry-scurry mice.

  3. Hurry-scurry (hscy)-2J, a mutation of Tmhs, causes abnormal splicing from a cryptic splice site within exon 2 that is predicted to produce a functionally null protein lacking 51 amino acids of the wild-type sequence.

LHFPL5 Protein Profile

Protein Summary

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis.

Gene names and symbols associated with LHFPL5

  • lipoma HMGIC fusion partner-like 5 (LHFPL5)
  • lipoma HMGIC fusion partner-like 5 (Lhfpl5)
  • 9330179O15Rik protein
  • DFNB67 protein
  • dJ510O8.8 protein
  • hscy protein
  • PMP22A protein
  • Tmhs protein

Protein level used designations for LHFPL5

LHFP-like protein 5 , lipoma HMGIC fusion partner-like 5 protein , tetraspan membrane protein of hair cell stereocilia , tetraspan transmembrane protein, hair cell stereocilia , peripheral myelin protein 22 , peripheral myelin protein 22a , tetraspan membrane protein of hair cell stereocilia homolog

GENE ID SPECIES
222662 Homo sapiens
328789 Mus musculus
294303 Rattus norvegicus
378916 Gallus gallus
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