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Lymphocyte Transmembrane Adaptor 1 Proteins (LAX1)

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells (By similarity). Additionally we are shipping LAX1 Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAX1 54900 Q8IWV1
LAX1 240754 Q8BHB3
Rat LAX1 LAX1 498232 Q5FVQ5
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Top LAX1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

LAX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Lymphocyte Transmembrane Adaptor 1 (LAX1) Interaction Partners

Human Lymphocyte Transmembrane Adaptor 1 (LAX1) interaction partners

  1. TRIM (show TRAT1 Proteins) required LAX for binding to Rab8 (show RAB8A Proteins) in a complex, a novel CTLA-4 (show CTLA4 Proteins)/TRIM (show TRAT1 Proteins)/LAX/Rab8 (show RAB8A Proteins) effector complex in the transport of CTLA-4 (show CTLA4 Proteins) to the surfaces of T cells

  2. We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins.

  3. Overexpression of LAX in Jurkat cells specifically inhibits T cell receptor-mediated p38 MAPK (show MAPK14 Proteins) activation and NFAT (show NFATC1 Proteins)/AP-1 (show FOSB Proteins) transcriptional activation.

  4. inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation.

Mouse (Murine) Lymphocyte Transmembrane Adaptor 1 (LAX1) interaction partners

  1. SIT and LAX are important negative regulators of immune responses that functionally cooperate.

  2. Upon T or B cell activation (show BLNK Proteins), the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling.

  3. LAX negatively regulates mast cell function

LAX1 Protein Profile

Protein Summary

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells (By similarity).

Gene names and symbols associated with LAX1

  • lymphocyte transmembrane adaptor 1 (LAX1)
  • lymphocyte transmembrane adaptor 1 (LOC100359066)
  • lymphocyte transmembrane adaptor 1 (Lax1)
  • A530029E09 protein
  • E430019B13Rik protein
  • LAX protein

Protein level used designations for LAX1

lymphocyte transmembrane adaptor 1 , lymphocyte transmembrane adapter 1-like , LAT-like membrane associated protein , linker for activation of x cells , lymphocyte transmembrane adapter 1 , membrane-associated adapter protein LAX , membrane associated adaptor protein LAX , linker for activation of X cells

GENE ID SPECIES
702011 Macaca mulatta
741370 Pan troglodytes
100359066 Oryctolagus cuniculus
100397361 Callithrix jacchus
100437319 Pongo abelii
100589202 Nomascus leucogenys
54900 Homo sapiens
540424 Bos taurus
240754 Mus musculus
498232 Rattus norvegicus
Selected quality suppliers for LAX1 Proteins (LAX1)
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