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KDM1A encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. Additionally we are shipping Lysine (K)-Specific Demethylase 1A Proteins (9) and Lysine (K)-Specific Demethylase 1A Kits (2) and many more products for this protein.
Showing 10 out of 197 products:
Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388023
Forneris, Binda, Vanoni, Mattevi, Battaglioli: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. in FEBS letters 2005
Show all 8 references for ABIN388023
Human Monoclonal KDM1A Primary Antibody for ChIP, ELISA - ABIN151289
Lim, Janzer, Becker, Zimmer, Schüle, Buettner, Kirfel: Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. in Carcinogenesis 2010
Show all 8 references for ABIN151289
Human Polyclonal KDM1A Primary Antibody for EIA, IHC (p) - ABIN356730
Bradley, van der Meer, Roodi, Yan, Chandrasekharan, Sun, Mernaugh, Parl: Carcinogen-induced histone alteration in normal human mammary epithelial cells. in Carcinogenesis 2007
Show all 7 references for ABIN356730
Human Polyclonal KDM1A Primary Antibody for EIA, IHC (p) - ABIN356728
Shi, Lan, Matson, Mulligan, Whetstine, Cole, Casero, Shi: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. in Cell 2004
Show all 6 references for ABIN356728
Human Polyclonal KDM1A Primary Antibody for IF, IHC (p) - ABIN388021
Hakimi, Dong, Lane, Speicher, Shiekhattar: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. in The Journal of biological chemistry 2003
Show all 6 references for ABIN388021
Human Polyclonal KDM1A Primary Antibody for IHC (p), WB - ABIN388022
Hakimi, Bochar, Chenoweth, Lane, Mandel, Shiekhattar: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 6 references for ABIN388022
Human Polyclonal KDM1A Primary Antibody for EIA, IHC (p) - ABIN356729
Humphrey, Wang, Russanova, Hirai, Qin, Nakatani, Howard: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. in The Journal of biological chemistry 2001
Show all 6 references for ABIN356729
Human Polyclonal KDM1A Primary Antibody for EIA, IHC (p) - ABIN500200
Kouzarides: Histone methylation in transcriptional control. in Current opinion in genetics & development 2002
Show all 4 references for ABIN500200
Human Polyclonal KDM1A Primary Antibody for EIA, WB - ABIN500198
Nakamura, Mori, Tada, Krajewski, Rozovskaia, Wassell, Dubois, Mazo, Croce, Canaani: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. in Molecular cell 2002
Show all 4 references for ABIN500198
Human Monoclonal KDM1A Primary Antibody for IHC, ELISA - ABIN969264
Shi, Matson, Lan, Iwase, Baba, Shi: Regulation of LSD1 histone demethylase activity by its associated factors. in Molecular cell 2005
Show all 2 references for ABIN969264
Data show that lysine-specific demethylase (show MBD2 Antibodies) 1 (LSD1) is a drug target for mixed lineage leukemia (MLL (show MLL Antibodies))-rearranged leukemia, and LSD1 inhibitors are potential therapeutics for the malignancy.
Results show that LSD1 is upregulated in human prostate cancer and plays an oncogenic role.
Authors found positive correlations between LSD1 expression and other proteins: epithelial-mesenchymal transition markers, C-myc (show MYC Antibodies) and cyclin (show PCNA Antibodies)-related proteins. Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc (show MYC Antibodies) expression and consequently inhibited GBC cell proliferation.
These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF (show EGF Antibodies) signaling.
these data suggest that KDM1A likely contains a histone H3 (show HIST3H3 Antibodies) secondary specificity element on the enzyme surface that contributes significantly to its recognition of substrates and products.
Overexpression of Lysine-Specific Demethylase (show MBD2 Antibodies) 1 Is Associated With Tumor Progression in Endometrioid Endometrial Adenocarcinoma.
When LSD1 activity was below 50%, pluripotency of human induced pluripotent stem cells was impaired
Based on the results and analysis, it may provide some useful information for future novel LSD1 inhibitor design.
Results support a model in which the HBXIP (show HBXIP Antibodies)/Hotair/LSD1 complex serves as a critical effector of c-Myc (show MYC Antibodies) in activating transcription of its target genes, illuminating long-standing questions on how c-Myc (show MYC Antibodies) drives carcinogenesis.
These data link the assembly of methylated KDM1A and CHD1 (show CHD1 Antibodies) with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2 (show TMPRSS2 Antibodies)-ERG (show ERG Antibodies) gene fusions during prostate-tumor evolution.
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Antibodies)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Antibodies)) expression and increasing the levels of histone demethylase (show MBD2 Antibodies) Lsd1 and transcription factor Brd4 (show BRD4 Antibodies) in B cell.
Deletion or reduction of isoform neuro LSD1 translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior.
Rcor2 (show Rcor2 Antibodies), a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.
GFI1 (show ZNF163 Antibodies) proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST (show Rcor2 Antibodies) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells
LSD1 is essential for oocyte meiotic progression by upregulating CDC25B (show CDC25B Antibodies) expression.
This study described how neuronal activity controls the neurospecific splicing of the epigenetic co-repressor LSD1 in mammalian nervous system.
LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 (show GATA2 Antibodies) locus.
Kdm1a is a master controller of gene transcription in spermatogonia and is required for SSC (show CYP11A1 Antibodies) and progenitor maintenance and differentiation.
KDM1A overexpression in one generation severely impaired development and survivability of offspring.
High LSD1 expression is associated with sickle cell anemia.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Antibodies) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase (show MBD2 Antibodies) activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 Antibodies) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase (show MBD2 Antibodies) activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
amine oxidase (flavin containing) domain 2
, lysine (K)-specific demethylase 1
, lysine (K)-specific demethylase 1A
, BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, flavin-containing amine oxidase domain-containing protein 2
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3