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Lysine (K)-Specific Demethylase 1A Proteins (KDM1A)

KDM1A encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. Additionally we are shipping Lysine (K)-Specific Demethylase 1A Antibodies (185) and Lysine (K)-Specific Demethylase 1A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM1A 23028 O60341
KDM1A 99982 Q6ZQ88
Rat KDM1A KDM1A 500569  
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Top Lysine (K)-Specific Demethylase 1A Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rice His tag   1 mg Log in to see 56 to 66 Days
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
HOST_Baculovirus Human DYKDDDDK Tag LSD1 / KDM1A activity assay. Recombinant LSD1 / KDM1A activity measure... Recombinant LSD1 / KDM1A protein gel. LSD1 / KDM1A protein was run on ... 20 μg Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

KDM1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Top referenced Lysine (K)-Specific Demethylase 1A Proteins

  1. Human KDM1A Protein expressed in Baculovirus infected Insect Cells - ABIN2005873 : Kusaba, Ito, Morita, Iida, Sato, Fujimoto, Kawasaki, Tanaka, Hirochika, Nishimura, Tanaka: Rice NON-YELLOW COLORING1 is involved in light-harvesting complex II and grana degradation during leaf senescence. in The Plant cell 2007 (PubMed)

More Proteins for Lysine (K)-Specific Demethylase 1A (KDM1A) Interaction Partners

Human Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. Authors found positive correlations between LSD1 expression and other proteins: epithelial-mesenchymal transition markers, C-myc (show MYC Proteins) and cyclin (show PCNA Proteins)-related proteins. Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc (show MYC Proteins) expression and consequently inhibited GBC cell proliferation.

  2. These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF (show EGF Proteins) signaling.

  3. these data suggest that KDM1A likely contains a histone H3 (show HIST3H3 Proteins) secondary specificity element on the enzyme surface that contributes significantly to its recognition of substrates and products.

  4. Overexpression of Lysine-Specific Demethylase 1 Is Associated With Tumor Progression in Endometrioid Endometrial Adenocarcinoma.

  5. When LSD1 activity was below 50%, pluripotency of human induced pluripotent stem cells was impaired

  6. Based on the results and analysis, it may provide some useful information for future novel LSD1 inhibitor design.

  7. Results support a model in which the HBXIP (show HBXIP Proteins)/Hotair/LSD1 complex serves as a critical effector of c-Myc (show MYC Proteins) in activating transcription of its target genes, illuminating long-standing questions on how c-Myc (show MYC Proteins) drives carcinogenesis.

  8. These data link the assembly of methylated KDM1A and CHD1 with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) gene fusions during prostate-tumor evolution.

  9. LSD1 is involved in pathophysiologic conditions including cancer [review]

  10. LSD1 may contribute to malignant behavior by regulating the invasive activity and metabolism, activating the glycolytic pathway and inhibiting the mitochondrial respiration of esophageal cancer cells

Mouse (Murine) Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase Lsd1 and transcription factor Brd4 (show BRD4 Proteins) in B cell.

  2. Deletion or reduction of isoform neuro LSD1 translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior.

  3. Rcor2 (show Rcor2 Proteins), a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.

  4. GFI1 (show ZNF163 Proteins) proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST (show Rcor2 Proteins) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells

  5. LSD1 is essential for oocyte meiotic progression by upregulating CDC25B (show CDC25B Proteins) expression.

  6. This study described how neuronal activity controls the neurospecific splicing of the epigenetic co-repressor LSD1 in mammalian nervous system.

  7. LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 (show GATA2 Proteins) locus.

  8. Kdm1a is a master controller of gene transcription in spermatogonia and is required for SSC (show CYP11A1 Proteins) and progenitor maintenance and differentiation.

  9. KDM1A overexpression in one generation severely impaired development and survivability of offspring.

  10. High LSD1 expression is associated with sickle cell anemia.

Zebrafish Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Proteins) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation

  2. Results indicate that LSD1 demethylase activity is required for neuromast development in zebrafish larvae.

Pig (Porcine) Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.

Arabidopsis thaliana Lysine (K)-Specific Demethylase 1A (KDM1A) interaction partners

  1. LSD1, EDS1, and PAD4 (show PADI4 Proteins) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.

  2. AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.

  3. AtLSD1, similar to HsLSD1, has demethylase activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]

Lysine (K)-Specific Demethylase 1A (KDM1A) Protein Profile

Protein Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM1A

  • amine oxidase (flavin containing) domain 2 (AOF2)
  • lysine (K)-specific demethylase 1 (KDM1)
  • lysine (K)-specific demethylase 1A (KDM1A)
  • lysine (K)-specific demethylase 1A (kdm1a)
  • lysine (K)-specific demethylase 1A (Kdm1a)
  • lysine (K)-specific demethylase 1a (kdm1a)
  • Lysine-specific histone demethylase 1-1 (LDL1)
  • 1810043O07Rik protein
  • AA408884 protein
  • Aof2 protein
  • ATLSD1 protein
  • ATSWP1 protein
  • BHC110 protein
  • D4Ertd478e protein
  • DKFZp459N2450 protein
  • F23N19.21 protein
  • F23N19_21 protein
  • Kdm1 protein
  • KDM1A protein
  • Lsd1 protein
  • LSD1-like 1 protein
  • mKIAA0601 protein
  • RGD1562975 protein
  • SWP1 protein
  • wu:fb82e06 protein
  • wu:fc51a02 protein
  • wu:fj36a05 protein
  • wu:fj66b06 protein
  • xLSD1 protein

Protein level used designations for KDM1A

amine oxidase (flavin containing) domain 2 , lysine (K)-specific demethylase 1 , lysine (K)-specific demethylase 1A , BRAF35-HDAC complex protein BHC110 , FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit , flavin-containing amine oxidase domain-containing protein 2 , lysine-specific histone demethylase 1 , lysine-specific histone demethylase 1A , neuroprotective protein 3 , lsd1

419571 Gallus gallus
456614 Pan troglodytes
718609 Macaca mulatta
100171870 Pongo abelii
100216250 Xenopus (Silurana) tropicalis
100557968 Anolis carolinensis
23028 Homo sapiens
99982 Mus musculus
478193 Canis lupus familiaris
500569 Rattus norvegicus
558450 Danio rerio
532997 Bos taurus
100127157 Sus scrofa
842582 Arabidopsis thaliana
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