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KDM1A encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. Additionally we are shipping Lysine (K)-Specific Demethylase 1A Antibodies (197) and Lysine (K)-Specific Demethylase 1A Kits (2) and many more products for this protein.
Showing 8 out of 9 products:
Human KDM1A Protein expressed in Baculovirus infected Insect Cells - ABIN2005873
Kusaba, Ito, Morita, Iida, Sato, Fujimoto, Kawasaki, Tanaka, Hirochika, Nishimura, Tanaka: Rice NON-YELLOW COLORING1 is involved in light-harvesting complex II and grana degradation during leaf senescence. in The Plant cell 2007
Data show that lysine-specific demethylase 1 (LSD1) is a drug target for mixed lineage leukemia (MLL (show MLL Proteins))-rearranged leukemia, and LSD1 inhibitors are potential therapeutics for the malignancy.
Results show that LSD1 is upregulated in human prostate cancer and plays an oncogenic role.
Authors found positive correlations between LSD1 expression and other proteins: epithelial-mesenchymal transition markers, C-myc (show MYC Proteins) and cyclin (show PCNA Proteins)-related proteins. Inhibiting LSD1 expression in vitro impaired the proliferation and invasiveness of GBC cells and also downregulated c-myc (show MYC Proteins) expression and consequently inhibited GBC cell proliferation.
These results highlight a novel mechanism regulating LSD1 expression and identify LSD1 as a promising therapeutic target for treating metastatic ovarian cancer driven by EGF (show EGF Proteins) signaling.
these data suggest that KDM1A likely contains a histone H3 (show HIST3H3 Proteins) secondary specificity element on the enzyme surface that contributes significantly to its recognition of substrates and products.
Overexpression of Lysine-Specific Demethylase 1 Is Associated With Tumor Progression in Endometrioid Endometrial Adenocarcinoma.
When LSD1 activity was below 50%, pluripotency of human induced pluripotent stem cells was impaired
Based on the results and analysis, it may provide some useful information for future novel LSD1 inhibitor design.
Results support a model in which the HBXIP (show HBXIP Proteins)/Hotair/LSD1 complex serves as a critical effector of c-Myc (show MYC Proteins) in activating transcription of its target genes, illuminating long-standing questions on how c-Myc (show MYC Proteins) drives carcinogenesis.
These data link the assembly of methylated KDM1A and CHD1 with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) gene fusions during prostate-tumor evolution.
Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase Lsd1 and transcription factor Brd4 (show BRD4 Proteins) in B cell.
Deletion or reduction of isoform neuro LSD1 translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior.
Rcor2 (show Rcor2 Proteins), a co-repressor of LSD1, controls neurogenesis in the developing mouse brain.
GFI1 (show ZNF163 Proteins) proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST (show Rcor2 Proteins) repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells
LSD1 is essential for oocyte meiotic progression by upregulating CDC25B (show CDC25B Proteins) expression.
This study described how neuronal activity controls the neurospecific splicing of the epigenetic co-repressor LSD1 in mammalian nervous system.
LSD1 mediates erythroid differentiation, via epigenetic modification of the GATA-2 (show GATA2 Proteins) locus.
Kdm1a is a master controller of gene transcription in spermatogonia and is required for SSC (show CYP11A1 Proteins) and progenitor maintenance and differentiation.
KDM1A overexpression in one generation severely impaired development and survivability of offspring.
High LSD1 expression is associated with sickle cell anemia.
results suggest that the LSD1-dependent shutdown of Etv2 (show ETV2 Proteins) gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Results indicate that LSD1 demethylase activity is required for neuromast development in zebrafish larvae.
LSD1 gene has two transcripts and is expressed in various tissues and relatively higher in ovary, kidney, and spleen.
LSD1, EDS1, and PAD4 (show PADI4 Proteins) participate in the regulation of various molecular and physiological processes that influence Arabidopsis fitness.
AtSWP1 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is unique to plants.
AtLSD1, similar to HsLSD1, has demethylase activity toward mono- and dimethylated Lys4 but not dimethylated Lys9 and Lys27 of histone 3. [LSD1]
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
amine oxidase (flavin containing) domain 2
, lysine (K)-specific demethylase 1
, lysine (K)-specific demethylase 1A
, BRAF35-HDAC complex protein BHC110
, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit
, flavin-containing amine oxidase domain-containing protein 2
, lysine-specific histone demethylase 1
, lysine-specific histone demethylase 1A
, neuroprotective protein 3