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Lysine (K)-Specific Demethylase 3A Proteins (KDM3A)

KDM3A encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Additionally we are shipping KDM3A Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat KDM3A KDM3A 682469  
KDM3A 55818 Q9Y4C1
KDM3A 104263 Q6PCM1
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Top KDM3A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Baculovirus Human DYKDDDDK Tag JMJD1A / KDM3A activity assay. Recombinant JMJD1A / KDM3A activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JMJD1A / KDM3A protein gel. JMJD1A / KDM3A protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KDM3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 3A (KDM3A) Interaction Partners

Human Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. JMJD1A-MALAT1-MAPK (show MAPK1 Proteins) signaling might participate in the JMJD1A-induced cell proliferation of gastric cancer.

  2. These results indicate that the KDM3A-KLF2 (show KLF2 Proteins)-IRF4 (show IRF4 Proteins) pathway plays an essential role in multiple myeloma cell survival and homing to the bone marrow, and therefore represents a therapeutic target.

  3. JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1 (show ADRB1 Proteins)) and downstream targets including Ucp1 (show UCP1 Proteins) in brown adipocytes.

  4. Loss of JMJD1A expression is associated with liver fibrosis.

  5. mitogen- and stress-activated protein kinase 1 (MSK1 (show RPS6KA5 Proteins)) specifically phosphorylates KDM3A at Ser264 (p-KDM3A), which is enriched in the regulatory regions of gene loci in the human genome.

  6. Studies identify the histone demethylase KDM3A as a new, miR (show MLXIP Proteins)-regulated, tumor promoter in Ewing Sarcoma.

  7. ACK1 (show TNK2 Proteins) interacts with KDM3A to regulate the mammary tumor oncogene (show RAB1A Proteins) HOXA1 (show HOXA1 Proteins).

  8. data identify a novel pathway through which N-Myc causes neuroblastoma cell migration and invasion, and provide important evidence for further development of more potent JMJD1A/MALAT1 inhibitors for the prevention of tumor metastasis.

  9. Studies found that JMJD1A was consistently and significantly downregulated at both RNA and protein levels in human germ cell tumors.

  10. JMJD1A forms a homodimer through its catalytic domains, bringing the two active sites close together

Cow (Bovine) Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. Histone demethylases KDM3A, KDM4A (show KDM4A Proteins), and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Proteins) was mainly expressed during the blastocyst period.

Mouse (Murine) Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1 (show ADRB1 Proteins)) and downstream targets including Ucp1 (show UCP1 Proteins) in brown adipocytes.

  2. Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin (show ACTB Proteins) and gamma-tubulin (show TUBG1 Proteins).

  3. Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor.

  4. Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity

  5. Jmjd1a directly and positively controls Sry (show SRY Proteins) expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.

  6. Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys (show LYZ Proteins)-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A.

  7. the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem (show CREM Proteins)-regulated gene expression and spermatogenesis

  8. TSGA may modulate the function of ER71 (show ETV2 Proteins) and thereby affect spermatogenesis as well as embryonic development

  9. Jmjd1a might be a critical signaling molecule underlying the maintenance of pluripotency in mouse embryonic stem cells

  10. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes.

KDM3A Protein Profile

Protein Summary

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM3A

  • lysine (K)-specific demethylase 3B (Kdm3b)
  • lysine (K)-specific demethylase 3A (kdm3a)
  • lysine (K)-specific demethylase 3A (KDM3A)
  • jumonji domain containing 1A (LOC100224407)
  • jumonji domain containing 1A (LOC100226356)
  • lysine (K)-specific demethylase 3A (kdm3a-b)
  • lysine (K)-specific demethylase 3A (Kdm3a)
  • 1700105C21Rik protein
  • C230043E16Rik protein
  • JHDM2a protein
  • JHMD2A protein
  • Jmjd1 protein
  • Jmjd1a protein
  • KDM2A protein
  • kdm3a protein
  • mKIAA0742 protein
  • TGSA protein
  • Tsga protein

Protein level used designations for KDM3A

lysine (K)-specific demethylase 3A , jumonji domain containing 1A , lysine-specific demethylase 3A-like , jmjC domain-containing histone demethylation protein 2A , jumonji domain-containing protein 1A-B , lysine-specific demethylase 3A-B , jumonji domain-containing protein 1A , lysine-specific demethylase 3A , jumonji C domain-containing histone demethylase 2A , jumonji domain containing 1 , testis-specific protein A , testis specific gene A , probable zinc finger protein , testis-specific gene A protein , zinc finger protein TSGA

GENE ID SPECIES
682469 Rattus norvegicus
100379807 Xenopus (Silurana) tropicalis
470424 Pan troglodytes
697775 Macaca mulatta
100224407 Taeniopygia guttata
100226356 Taeniopygia guttata
100080666 Ornithorhynchus anatinus
100402409 Callithrix jacchus
100453519 Pongo abelii
100482264 Ailuropoda melanoleuca
100602862 Nomascus leucogenys
496351 Xenopus laevis
422917 Gallus gallus
55818 Homo sapiens
475763 Canis lupus familiaris
536073 Bos taurus
104263 Mus musculus
312440 Rattus norvegicus
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