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Lysine (K)-Specific Demethylase 5C Proteins (KDM5C)

KDM5C is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. Additionally we are shipping KDM5C Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM5C 8242 P41229
KDM5C 20591 P41230
KDM5C    
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Top KDM5C Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,423.67
Details
HOST_Baculovirus Human DYKDDDDK Tag JARID1C / KDM5C activity assay. Recombinant JARID1C / KDM5C activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1C / KDM5C protein gel. JARID1C / KDM5C protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details

KDM5C Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Cricetulus griseus

More Proteins for Lysine (K)-Specific Demethylase 5C (KDM5C) Interaction Partners

Human Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. KDM5C is overexpressed in breast cancer cells and miR (show MLXIP Proteins)-138 regulates its expression.

  2. study of non-synonymous mutations in the KDM5C ARID domain and evaluates effects of 2 syndromic Claes-Jensen-type disease-associated missense mutations (A77T and D87G) and 3 non-classified missense mutations (R108W, N142S, and R179H); analysis indicates, among the non-classified mutations, R108W is possibly a disease-associated mutation, and N142S and R179H are probably harmless

  3. Findings reveal a RACK7/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis.

  4. Expression of KDM5C in hepatocellular carcinoma tumor cells promoted cell migration and tumor invasion.

  5. Characterization of a Linked Jumonji (show JARID2 Proteins) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Proteins) Lysine 4 Demethylases.

  6. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

  7. Mutations in KDM5C gene in patients are described and their effect on gene expression, stability and catalytic activity is examined. Patient fibroblasts do not show global changes in histone methylation but several up-regulated genes were identified.

  8. BRMS1 (show BRMS1 Proteins) expression in human breast cancer is negatively correlated with JARID1C expression. Our results, for the first time, portray a pivotal role of JARID1C in regulating metastatic behaviors of breast cancer cells

  9. Data indicate the role for histone demethylase KDM5C/JARID1C in a specific phase of DNA replication in mammalian cells, through its demethylase activity on histone H3K4me3.

  10. KDM5C is functionally involved in proliferation control of prostate cancer cells

Mouse (Murine) Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.

  2. The present study was designed to detect the expression of Histone H3 (show HIST3H3 Proteins) lysine 4 methylation and its demethylases LSD1 (show KDM1A Proteins), RBP2 (show RBP2 Proteins) and SMCX in 21-, 40- and 60-day-old mouse testes.

  3. Kdm5c protein restricts transcriptional output at promoters, whereas Kdm5c binding to enhancers stimulates their activity.

  4. sex-specific expression of Jarid1c may contribute to sex differences in brain function

  5. allelic expression and RNA/DNA FISH indicate that transgenic Jarid1c escapes X inactivation.

Pig (Porcine) Lysine (K)-Specific Demethylase 5C (KDM5C) interaction partners

  1. The full-length cDNA of JARID1C has been cloned.

KDM5C Protein Profile

Protein Summary

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KDM5C

  • histone demethylase JARID1C (MGYG_04221)
  • lysine (K)-specific demethylase 5C (KDM5C)
  • lysine (K)-specific demethylase 5C (kdm5c)
  • lysine (K)-specific demethylase 5C (Kdm5c)
  • DXS1272E protein
  • Jarid1c protein
  • mKIAA0234 protein
  • MRXJ protein
  • MRXSCJ protein
  • MRXSJ protein
  • Smcx protein
  • XE169 protein

Protein level used designations for KDM5C

histone demethylase JARID1C , lysine (K)-specific demethylase 5C , jumonji, AT rich interactive domain 1C , JmjC domain-containing protein SMCX , Jumonji, AT rich interactive domain 1C (RBP2-like) , Jumonji/ARID domain-containing protein 1C , Smcx homolog, X chromosome , Smcy homolog, X-linked , lysine-specific demethylase 5C , protein SmcX , selected cDNA on X , jumonji, AT rich interactive domain 1C (Rbp2 like) , jumonji/ARID domain-containing protein 1C , selected mouse cDNA on the X , lysine (K)-specific demethylase 5C tv1 , Lysine-specific demethylase 5C

GENE ID SPECIES
10029336 Arthroderma gypseum CBS 118893
100075501 Ornithorhynchus anatinus
100341721 Oryctolagus cuniculus
100565551 Anolis carolinensis
8242 Homo sapiens
20591 Mus musculus
491894 Canis lupus familiaris
100037295 Sus scrofa
281490 Bos taurus
100758549 Cricetulus griseus
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