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LPAR2 encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. Additionally we are shipping Lysophosphatidic Acid Receptor 2 Antibodies (76) and many more products for this protein.
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LPAR2 signaling is required for in vivo neural crest cell migration.
LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels
epithelial dysplasia was observed in founder mouse intestine, correlating LPA2 overexpression with epithelial dysplasia. The current study demonstrates that overexpression of LPA2 alone can lead to intestinal dysplasia.
LPA2 expression was associated with HIF-1alpha (show HIF1A Proteins) expression and that a high level of LPA2 was associated with shorter overall survival and was an independent prognostic predictor for breast cancer in Chinese women.
LPAR2 mRNA is up-regulation in colorectal cancer.
Data show high expression levels of LPAR2 and LPAR1 (show LPAR1 Proteins) in endometrial cancer tissue with positive correlations with FIGO stage suggesting them as potential biomarkers for endometrial cancer progression.
Suggest that LPA2 and LPA3 (show LPAR3 Proteins) may function as a molecular switch and play opposing roles during megakaryopoiesis of K562 cells.
the RhoA (show RHOA Proteins)-regulated formin (show FMN1 Proteins) Dia1 (show CYB5R3 Proteins) is involved in entosis downstream of LPAR2
Crystal structure of NHERF2 (show SLC9A3R2 Proteins) PDZ1 domain complex with C-terminal LPA2 sequence. The PDZ1-LPA2 binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 residues contributing to specific interactions.
LPA1 (show LPAR1 Proteins) and LPA2 are major LPA (show APOA Proteins) receptor subtypes compared with low-expressed LPA3 (show LPAR3 Proteins) in PANC-1 tumor cells.
Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent.
Pharmacologic activation of LPA2 attenuates Th2-driven allergic airway inflammation in a mouse model of asthma.
These findings identify ATX (show ENPP2 Proteins) and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.
Lysophosphatidic acid gradients induce a spatiotemporally restricted decrease in the mobility of LPA receptor 2 (LPA2) on chemotactic fibroblasts.
Lysophosphatidic acid signals through LPA2 receptors and Galphaq (show GNAQ Proteins) proteins of cultured proximal tubule cells to transactivate latent TGF-beta (show TGFB1 Proteins) in a Rho/Rho-kinase (show ROCK2 Proteins) and alphavbeta6 integrin-dependent manner.
these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation.
LPA(1 (show LPAR1 Proteins)-3) are differentially expressed in the central nervous system and their expression is upregulated in response to injury.
LPA (lysophosphatidic acid) receptors couple to Gq in VSMC (vascular smooth muscle cells)and mediate migration and proliferation which may be mediated through activation of ERK1/2 and Akt (show AKT1 Proteins).
lysophosphatidic acid 2 (show PTOV1 Proteins) receptor mediates down-regulation of Siva-1 (show SIVA1 Proteins) to promote cell survival
A novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis.
Enhanced expression of LPA2 Receptor induce a bypass of p19ARF-p53 (show TP53 Proteins)-dependent senescence.
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
, GHRH receptor
, GRF receptor
, growth hormone-releasing hormone receptor
, pituitary growth hormone releasing hormone receptor
, G protein-coupled receptor
, LPA receptor 2
, LPA receptor EDG4
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
, lysophosphatidic acid receptor EDG4
, lysophosphatidic acid receptor Edg-4
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4
, pre-B-cell leukemia transcription factor 4