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Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Additionally we are shipping LPAR4 Antibodies (67) and LPAR4 Kits (4) and many more products for this protein.
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These results suggest that the diverse roles of LPA4, LPA5 (show LPAR5 Proteins) and LPA6 (show LPAR6 Proteins) are involved in the activation of tumor progression in pancreatic cancer cells.
Our data suggest that LPA4 signaling potentially modulates malignant behavior of SQ-20B cells.
LPA4 gene mutation may play some role in the pathogenesis of colon cancer.
LPA4 and LPA5 (show LPAR5 Proteins) receptors induce osteoblastic differentiation of human mesenchymal stem cells
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
identified as the fourth lysophosphatidic acid (LPA (show APOA Proteins)) receptor; shares only 20-24% amino acid identities with Edg-2/LPA1 (show LPAR1 Proteins), Edg-4/LPA2 (show LPAR2 Proteins), and Edg-7/LPA3 (show LPAR3 Proteins), and phylogenetic analysis also shows that p2y9/GPR23 is far distant from the Edg family
The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
Affymetrix expression profiling shows that the C terminus of Runx2 (show RUNX2 Proteins) regulates genes involved in G protein-coupled receptor (show GPR34 Proteins) signaling Rgs2 (show RGS2 Proteins), Rgs4 (show RGS4 Proteins), Rgs5 (show RGS5 Proteins), Rgs16 (show RGS16 Proteins), Gpr23, Gpr30, Gpr54, Gpr64, and Gna13 (show GNA13 Proteins).
a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc (show MYC Proteins)
These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.
G protein-coupled receptor 23
, G-protein coupled receptor 23
, LPA receptor 4
, P2Y purinoceptor 9
, P2Y5-like receptor
, purinergic receptor 9