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Lysyl Oxidase Proteins (LOX)

The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Additionally we are shipping LOX Antibodies (141) and LOX Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LOX 4015 P28300
LOX 16948 P28301
LOX 24914 P16636
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Top LOX Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag Lysyl Oxidase (LOX) (AA 163-411) protein (His tag) expressed in E. coli 1 mg Log in to see 56 to 66 Days
$2,638.17
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,638.17
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,638.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,638.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

LOX Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,
Rat (Rattus) ,

More Proteins for Lysyl Oxidase (LOX) Interaction Partners

Zebrafish Lysyl Oxidase (LOX) interaction partners

  1. Partial knockdown of lysyl oxidase genes sensitizes the developing embryo to dithiocarbamate exposure.

  2. Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.

Human Lysyl Oxidase (LOX) interaction partners

  1. LOX gene expression was approximately 2.5-fold higher in fetal membranes from preterm prelabor rupture of membranes (pPROM (show SERPINH1 Proteins)) compared to preterm and term birth.

  2. The data suggest a fibromodulin (show FMOD Proteins)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD Proteins) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

  3. Cu chaperone function of Atox1 (show ATOX1 Proteins) mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase.

  4. Our study demonstrated that the LOX rs1800449 genotypes (AA and GA + AA) and allele (A) appears to confer risk for susceptibility to keratoconus.

  5. Individuals with LOX variants had fusiform enlargement of the aortic root and ascending thoracic aorta, leading to ascending aortic dissections.

  6. two LOX variants, rs2956540 and rs10519694, may affect individual susceptibility to keratoconus

  7. LOX expression at the mRNA and protein level, and enzymatic activity were remarkably upregulated in the hypoxic A549 cells, compared with normoxic A549 cells.

  8. Aortic tissue from Marfan syndrome patients and display enhanced expression of the members of the LOX family, LOX and LOX-like 1.

  9. Evidence for association was found for both of the tested loci.It was strongest for rs3735520:G>A near HGF (show HGF Proteins) with A allele being a risk factor and rs2956540:G>C within LOX with C allele having a protective effect

  10. Using principal component analysis (PCA (show FLVCR1 Proteins)), the authors identified a LOX/hypoxia signature associated with poor patient survival in resectable pancreatic ductal adenocarcinoma patients.

Pig (Porcine) Lysyl Oxidase (LOX) interaction partners

  1. Statins normalize vascular lysyl oxidase (LOX) down-regulation induced by proatherogenic risk factors.

Cow (Bovine) Lysyl Oxidase (LOX) interaction partners

  1. These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.

  2. Lysyl oxidase enhances elastin (show ELN Proteins) synthesis and matrix formation by vascular smooth muscle cells

  3. Lysyl oxidase has a role in oxidizing basic fibroblast growth factor (show FGF2 Proteins) and inactivating its mitogenic potential

  4. In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.

  5. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.

Mouse (Murine) Lysyl Oxidase (LOX) interaction partners

  1. LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery

  2. Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.

  3. The data suggest a fibromodulin (show FMOD Proteins)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD Proteins) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.

  4. Data suggest of pharmacologic targeting of lysyl oxidase (LOX) pathway to inhibit liver fibrosis and promote its resolution.

  5. Cu chaperone function of Atox1 (show ATOX1 Proteins) mediated through Cu transporter ATP7A (show ATP7A Proteins) is required for VEGF (show VEGFA Proteins)-induced angiogenesis via activation of Cu enzyme lysyl oxidase.

  6. CTR1 (show SLC31A1 Proteins), ATP7A (show ATP7A Proteins), and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.

  7. Inhibition of tissue transglutaminase (show TGM2 Proteins) resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction.

  8. decreased expression of cross-linking enzymes (LOXs) and increased expression of ECM (show MMRN1 Proteins)-degrading proteinases (MMP-1 (show MMP1 Proteins), 2, 3) might be of great contribution to poor healing ability of PCL (show PKD2L1 Proteins) ligament

  9. LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury.

  10. LOX and LOXL2 (show LOXL3 Proteins) may play an important role in the pathogenesis of AMD (show AMD1 Proteins). Targeting LOXL2 (show LOXL3 Proteins) could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis.

LOX Protein Profile

Protein Summary

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Lysyl Oxidase Proteins (LOX)

  • lysyl oxidase (LOX)
  • lysyl oxidase (lox)
  • lysyl oxidase (Lox)
  • lysyl oxidase (LOC100357045)
  • AI893619 protein
  • H-rev142 protein
  • lox protein
  • MGC146507 protein
  • Rrg1 protein
  • TSC-160 protein
  • Xlox protein
  • zgc:77447 protein

Protein level used designations for Lysyl Oxidase Proteins (LOX)

lysyl oxidase , protein-lysine 6-oxidase-like , protein-lysine 6-oxidase , ras excision protein , ras recision gene (rrg) , Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)

GENE ID SPECIES
471614 Pan troglodytes
699997 Macaca mulatta
780067 Xenopus (Silurana) tropicalis
100189621 Oncorhynchus mykiss
100457685 Pongo abelii
404621 Danio rerio
734204 Xenopus laevis
4015 Homo sapiens
100525278 Sus scrofa
280841 Bos taurus
16948 Mus musculus
24914 Rattus norvegicus
396474 Gallus gallus
481478 Canis lupus familiaris
100720740 Cavia porcellus
100357045 Oryctolagus cuniculus
101112220 Ovis aries
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