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LOXL3 encodes a member of the lysyl oxidase gene family. Additionally we are shipping LOXL3 Antibodies (40) and LOXL3 Kits (12) and many more products for this protein.
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By deacetylating and deacetyliminating Stat3 (show STAT3 Proteins) on multiple acetyl-lysine sites in nuclei, Loxl3 regulates Stat3 (show STAT3 Proteins) dimerization and transcriptional activity. CD4 (show CD4 Proteins)+ T cell differentiation in inflammatory responses is regulated by the Loxl3-Stat3 (show STAT3 Proteins) signaling pathway
evidence that LOXL3 is indispensable for mouse palatogenesis and vertebral column development
that lysyl oxidase-like 3 is a key regulator of integrin signaling that ensures localized control of the cascade
Our results suggest that null mutations in LOXL3 are likely associated with autosomal recessive early-onset high myopia. LOXL3 is a potential candidate gene for high myopia, but this possibility should be confirmed in additional studies.
LOXL3 is a novel candidate gene for autosomal recessive Stickler syndrome.
TGF-beta1 (show TGFB1 Proteins) induced injured MCL (show FH Proteins) to express more LOXs than injured ACL (show ACLY Proteins) (up to 1.85-fold in LOX (show LOX Proteins), 2.21-fold in LOXL-1 (show LOXL1 Proteins), 1.71-fold in LOXL-2 (show LOXL2 Proteins), 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4 (show LOXL4 Proteins)).
The human lysyl oxidase-like 3 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis.
Lysyl-oxidase-like 3 interacts and cooperates with Snail (show SNAI1 Proteins) to downregulate E-cadherin (show CDH1 Proteins) expression, and control epithelial-mesenchymal transitions and carcinoma progression.
LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of which function as amine oxidases with distinct tissue and substrate specificities from one another.
Breast carcinoma effusions showed significantly higher LOXL2 (show LOXL2 Proteins) and lower LOXL3 expression compared to primary carcinomas.
Expression of LOXL (show LOXL1 Proteins), LOXL2 (show LOXL2 Proteins), LOXL3 and LOXL4 (show LOXL4 Proteins) was not statistically associated with tumor location, stage, growth type, or differentiation status in colorectal adenocarcinomas
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
lysyl oxidase homolog 3
, lysyl oxidase-like 3
, lysyl oxidase homolog 3-like
, lysyl oxidase-like 2
, lysyl oxidase-like protein 3
, lysyl oxidase-related protein 2