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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2L1 Proteins (8) and many more products for this protein.
Showing 10 out of 114 products:
Human Monoclonal MAD2L1 Primary Antibody for IP, WB - ABIN400793
Sudakin, Yen: Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells. in Methods in molecular biology (Clifton, N.J.) 2004
Show all 7 references for ABIN400793
Human Polyclonal MAD2L1 Primary Antibody for EIA, WB - ABIN117979
Sze, Ching, Jin, Ng: Association of MAD2 expression with mitotic checkpoint competence in hepatoma cells. in Journal of biomedical science 2004
Show all 5 references for ABIN117979
Human Monoclonal MAD2L1 Primary Antibody for WB - ABIN395553
Hewitt, Tighe, Santaguida, White, Jones, Musacchio, Green, Taylor: Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. in The Journal of cell biology 2010
Show all 5 references for ABIN395553
Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108556
Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. in Journal of clinical pathology 2007
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Human Monoclonal MAD2L1 Primary Antibody for IP, WB - ABIN567786
Wei, Chou, Ou, Yeh, Tyan, Sun, Shen, Shieh: TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. in The Journal of biological chemistry 2005
Show all 2 references for ABIN567786
Human Polyclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN1452186
Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. in Science (New York, N.Y.) 1996
Chicken Polyclonal MAD2L1 Primary Antibody for WB - ABIN2792179
Hisaoka, Matsuyama, Hashimoto: Aberrant MAD2 expression in soft-tissue sarcoma. in Pathology international 2008
p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Antibodies)
study shows that Mad2 (show MXI1 Antibodies) is a novel substrate for CCP6 (show AGBL4 Antibodies) in megakaryocytes; Mad2 (show MXI1 Antibodies) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (show CENPE Antibodies)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Antibodies), Mad2 (show MXI1 Antibodies), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (show MXI1 Antibodies) is also repressed by p53 (show TP53 Antibodies) and its upregulation is required for chromosome instability in a p53 (show TP53 Antibodies) mutant tumor model
Data show that Mad2 (show MXI1 Antibodies) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Antibodies) inhibitor in vitro.
Pcid2 (show PCID2 Antibodies) is essential for B cell survival through the regulation of MAD2 (show MXI1 Antibodies) expression during B cell differentiation
tumours that experience transient Mad2 (show MXI1 Antibodies) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (show MXI1 Antibodies)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
Data show that the loss of Trrap (show TRRAP Antibodies) leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap (show TRRAP Antibodies)-mediated transcription of the mitotic checkpoint (show BUB3 Antibodies) proteins Mad1 (show MXD1 Antibodies) and Mad2 (show MXI1 Antibodies).
that Brca1 (show BRCA1 Antibodies)(Delta11/Delta11) cells displayed decreased expression of a number of genes that are involved in the spindle checkpoint, including Mad2 (show MXI1 Antibodies)
Studied the folding/unfolding process of the open and closed conformers of human Mad2.
MAD1L1 (show MAD1L1 Antibodies) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
p31comet-induced cell death is mediated by interactions with Mad2
MAD2L1 and BUB1 (show BUB1 Antibodies) may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
We also show that replication perturbations result in relocalization of MAD1 (show MXD1 Antibodies)/MAD2 in human cells, suggesting that the role of SAC (show ADCY10 Antibodies) in DNA repair is conserved.
Data indicate the structure of the intermediate conformer of the multistate checkpoint protein mitotic arrest deficient 2 (Mad2) protein.
WT1 (show WT1 Antibodies) has a role in interacting MAD2 and regulating mitotic checkpoint (show BUB3 Antibodies) function
In conclusion, the results presented here suggest that Mad2 and BubR1 (show BUB1B Antibodies) could be used as prognostic markers of tumor progression and new pharmacological targets in the treatment for gastric cancer .
Co-depletion of MAD2 and BUBR1 (show BUB1B Antibodies) causes cell cycle arrest and cell death in addition to aneuploidy.
hMAD2 also binds to the hREV7 (show MAD2L2 Antibodies)-binding sequence in hREV3 (show REV3L Antibodies), whereas hMAD2 does not bind to a similar sequence in ADAM9 (show ADAM9 Antibodies) or ELK-1 (show ELK1 Antibodies) and hREV7 (show MAD2L2 Antibodies) does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
, mitotic spindle assembly checkpoint protein MAD2A
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1 (yeast)
, MAD2 mitotic arrest deficient-like 1
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, mitotic arrest deficient, yeast, homolog-like 1