MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) Proteins (MAD2L1)

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2L1 Antibodies (136) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAD2L1 56150 Q9Z1B5
MAD2L1 4085 Q13257
Rat MAD2L1 MAD2L1 297176  
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Top MAD2L1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Human MAD2L1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 15 to 19 Days
$319.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$382.86
Details

MAD2L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
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More Proteins for MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaction Partners

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. Mad2 (show MXI1 Proteins)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

  2. reduced MAD2 (show MXI1 Proteins) levels attenuate the apoptotic response to mis (show AMH Proteins)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  3. p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 Proteins)

  4. study shows that Mad2 (show MXI1 Proteins) is a novel substrate for CCP6 (show AGBL4 Proteins) in megakaryocytes; Mad2 (show MXI1 Proteins) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  5. Exacerbating chromosome missegregation in CENP-E (show CENPE Proteins)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 Proteins), Mad2 (show MXI1 Proteins), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  6. Mad2 (show MXI1 Proteins) is also repressed by p53 (show TP53 Proteins) and its upregulation is required for chromosome instability in a p53 (show TP53 Proteins) mutant tumor model

  7. Data show that Mad2 (show MXI1 Proteins) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 Proteins) inhibitor in vitro.

  8. Pcid2 (show PCID2 Proteins) is essential for B cell survival through the regulation of MAD2 (show MXI1 Proteins) expression during B cell differentiation

  9. tumours that experience transient Mad2 (show MXI1 Proteins) overexpression and consequent chromosome instability recur at markedly elevated rates

  10. a functional Mad2 (show MXI1 Proteins)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. TRAP1 (show TRAP1 Proteins) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 Proteins)/TBP7 (show PSMC4 Proteins) quality control of CDK1 (show CDK1 Proteins) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  2. Thes authors show that p31 (show ATP6V1E1 Proteins)(comet) binding to the TRIP13 (show TRIP13 Proteins) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 Proteins) "pore loops", which then unfold MAD2 in the presence of ATP.

  3. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 Proteins) complex assembly

  4. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB Proteins).

  5. Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (show BGN Proteins)-DLBCL. Mad2 overexpression indicated a poor DFS (show FST Proteins).

  6. interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (show CDC20 Proteins) inhibition.

  7. we showed that BubR1 (show BUB1B Proteins) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.

  8. Studied the folding/unfolding process of the open and closed conformers of human Mad2.

  9. MAD1L1 (show MAD1L1 Proteins) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer

  10. p31comet-induced cell death is mediated by interactions with Mad2

MAD2L1 Protein Profile

Protein Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Gene names and symbols associated with MAD2L1

  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (MAD2L1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (LOC100218172)
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1)
  • MAD2 mitotic arrest deficient-like 1 (yeast) (Mad2l1)
  • AA673185 protein
  • cb408 protein
  • HSMAD2 protein
  • MAD2 protein
  • MAD2L1 protein
  • XMad2 protein
  • zgc:112133 protein

Protein level used designations for MAD2L1

MAD2-like 1 , mitotic spindle assembly checkpoint protein MAD2A , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 (yeast) , MAD2 mitotic arrest deficient-like 1 , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , mitotic arrest deficient, yeast, homolog-like 1

GENE ID SPECIES
461661 Pan troglodytes
550434 Danio rerio
708574 Macaca mulatta
787996 Bos taurus
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
56150 Mus musculus
380433 Xenopus laevis
4085 Homo sapiens
422675 Gallus gallus
476070 Canis lupus familiaris
337870 Bos taurus
297176 Rattus norvegicus
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