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Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Additionally we are shipping and and many more products for this protein.
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The MDGA1 gene may confer risk to schizophrenia and bipolar disorder in Chinese Han population.
A novel human gene mapped to chromosome 6p21, encodes a putative glycosylphosphatidylinositol (GPI (show GNPDA1 ELISA Kits)) anchored protein containing a MAM (show ATF7IP ELISA Kits) (meprin, A5 antigen (show NRP1 ELISA Kits), protein tyrosine phosphatase mu (show PTPRM ELISA Kits)) domain. (GPIM)
MDGA1, a novel glycosylphosphatidylinositol-anchored protein, is localized in lipid rafts.
MDGA1 is a new schizophrenia susceptibility gene, and altered neuronal migration is involved in SZ pathology.
Mdga1 is involved in the migration and positioning of a subset of cortical neurons and the radial migration of upper-layer neurons might be differentially regulated.
We conclude that MDGA1 acts cell autonomously to control the migration of MDGA1-expressing superficial layer cortical neurons.
These findings show that MDGA1 is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development.
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity).
GPI and MAM protein
, MAM domain-containing glycosylphosphatidylinositol anchor protein 1
, MAM domain-containing protein 3