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Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (By similarity).. Additionally we are shipping MARVELD1 Antibodies (14) and many more products for this protein.
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MARVELD1 is a microtubule-associated protein (show SPAG5 Proteins) that plays an important role in cell cycle progression and migration
MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 (show UPF1 Proteins) and Y14 (show RBM8A Proteins). MARVELD1 promotes the dissociation of SMG1 from UPF1 (show UPF1 Proteins), resulting in the repression of serine phosphorylation of UPF1 (show UPF1 Proteins), and subsequently blocks the recruitment of SMG5 (show SMG5 Proteins).
Study demonstrates that MARVELD1-mediated balance of integrin beta1 and beta4 regulates cell surface ultrastructure and epithelial-mesenchymal transition phenotype of non-small cell lung cancer (NSCLC).
MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer.
Importin-beta1 mediates the non-classical nucleocytoplasmic transport of MARVELD1.
MARVELD1 plays a role in pre-mRNA processing (show PRPF39 Proteins) of integrin beta1.
Our findings suggest that MARVELD1 is a tumor suppressor by negatively regulating proliferation, tumor growth and chemosensitivity of HCC cells via increasing p53 and p16 in vitro and in vivo.
MARVELD1 protein is located in nucleus instead of cell membrane in several different tumors, in males and in females.
Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration (By similarity).
MARVEL (membrane-associating) domain containing 1
, MARVEL domain-containing protein 1
, putative MARVEL domain-containing protein 1