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Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Additionally we are shipping MRGBP Antibodies (57) and many more products for this protein.
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Human MRGBP Protein expressed in Escherichia coli (E. coli) - ABIN667621
Doyon, Selleck, Lane, Tan, Côté: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. in Molecular and cellular biology 2004
Show all 2 references for ABIN667621
MRGBP contributes to colorectal carcinogenesis through rendering advantages in cell proliferation and/or division of cancer cells.
These results suggest that C20orf20 protein has an important function in proliferation of cancer cells through the regulation of BRD8 (show BRD8 Proteins) protein.
MRGBP is encoded by the FLJ10914 ORF and is a new component of the TRRAP/TIP60 HAT complex
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
, mrg-binding protein
, MRG(MORF4-related gene)-binding protein
, MRG/MORF4L-binding protein