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MVP encodes the major component of the vault complex. Additionally we are shipping Major Vault Protein Antibodies (199) and Major Vault Protein Kits (33) and many more products for this protein.
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structure and cellular localization during embryonic development; findings indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea (show Slc25a1 Proteins) urchin embryogenesis
Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity
Study found significant upregulation of MVP and BCRP whereas MRP1 (show MDM4 Proteins) and UGT1A4 (show UGT1A4 Proteins) were unaltered in drug resistant epilepsy brains. While upregulation of BCRP was significantly higher in mesial temporal lobe epilepsy (9.34+/-0.45; p<0.05), upregulation of MVP was significantly higher in focal cortical dysplasia (2.94+/-0.65; p<0.01).
Taxus chinensis var.-mediated downregulation of MRP1 (show MDM4 Proteins), MDR1, and LRP (show RPSA Proteins) might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.
We believe that for the first time, genetic variants at XRCC6 (show XRCC6 Proteins) and MVP genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer
MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population.
NSCLCs [ non-small cell lung cancer ] expressing P-gp (show ABCB4 Proteins) [P-glycoprotein ]/LRP (show RPSA Proteins) [ lung resistance-related protein] bear the EGFR (show EGFR Proteins) [epidermal growth factor receptor (show EGFR Proteins)] mutation in exon 19 or 21 easily.
The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma.
Bag3 (show BAG3 Proteins)-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer
LDL increases ABCB1 (show ABCB1 Proteins), ABCC1 (show ABCC1 Proteins), and LRP (show RPSA Proteins) expression in a human doxorubicin-resistant uterine sarcoma cell line.
Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)-mediated migration and survival pathways in human glioblastoma.
MVP may fine-tune SR-A (show MSR1 Proteins) activity in macrophages which contributes to the development of atherosclerosis
MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.
These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling.
Results suggest that major vault protein functions as a novel scaffold protein (show HOMER1 Proteins) for both SHP-2 (show PTPN11 Proteins) and Erk (show EPHB2 Proteins).
results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection
The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, provide an explanation for a reversible dissociation induced by low pH.
MVP is beneficial for functional recovery and axonal regrowth after spinal cord injury in adult zebrafish.
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
major vault protein
, major vault protein-alpha
, major vault protein B
, lung resistance-related protein
, lung resistance-associated protein
, protein tyrosine phosphatase alpha
, protein-tyrosine phosphatase alpha
, receptor-type tyrosine-protein phosphatase alpha