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The membrane-associated protein encoded by Mod2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping and many more products for this protein.
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Single nucleotide polymorphism C3435T (rs1045642) within MDR1 (show TBC1D9 Antibodies) gene may be associated with an increased expression of P-gp (show ABCB4 Antibodies) which affects the levels of antiepileptic drugs in plasma. The presented studies analysed the association between C3435T polymorphism of MDR1 (show TBC1D9 Antibodies) gene and the incidence of drug-resistant epilepsy in the population of Polish children.
found that the MDR1 (show TBC1D9 Antibodies) C3435T polymorphisms did not play an important role as a genetic risk factor for the development and progression of childhood ITP (show ITPA Antibodies). However, patients carrying MDR1 (show TBC1D9 Antibodies) (CC) genotypes had a higher risk to develop childhood ITP (show ITPA Antibodies) at an older age and having lower initial platelet count than patients carrying other genotype
We analyzed TNFalpha (show TNF Antibodies), NOS 3 (show NANOS3 Antibodies) and MDR1 (show TBC1D9 Antibodies) in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP.
ABCB1 (show ABCB1 Antibodies) gene variants could affect the pharmacodynamics of rocuronium.
C3435T polymorphism in the MDR1 (show TBC1D9 Antibodies) gene appears not to be associated with sustained virological response in HCV-HIV co-infected individuals.
The expression of ABCB1 (show ABCB1 Antibodies), ABCC1 (show ABCC1 Antibodies) and ABCG2 (show ABCG2 Antibodies) on primary human T-cells correlates with the efficacy of JAK (show JAK3 Antibodies) inhibitor ruxolitinib treatment in regard to T-cell activation and proliferation.
There were no significant differences in the AUC0-24 of O-desmethyl gefitinib between ABCB1 (show ABCB1 Antibodies) and ABCG2 (show ABCG2 Antibodies) genotypes.
Data show that the CAV1 (show CAV1 Antibodies) K176R mutant blocks the interaction with P-glycoprotein and abolishes the inhibition of P-glycoprotein by CAV1 (show CAV1 Antibodies). These effects contribute to the understanding of the regulation of P-glycoprotein and drug resistance in cancer cells.
Deletions of ABCB1 (show ABCB1 Antibodies) predict good tumor response to neoadjuvant chemotherapy in breast cancer.
miR-21 may modulate the sensitivity to PTX, at least in part, by regulating the expression of P-glycoprotein
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
malic enzyme complex, mitochondrial
, malic enzyme, mitochondrial regulatory
, malic enzyme, mitochondrial structural
, P-glycoprotein 1
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1