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Mannosidase, Alpha, Class 1B, Member 1 Proteins (MAN1B1)

MAN1B1 encodes an enzyme belonging to the glycosyl hydrolase 47 family. Additionally we are shipping MAN1B1 Antibodies (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MAN1B1 11253 Q9UKM7
MAN1B1 227619 A2AJ15
MAN1B1 499751 B2GUY0
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Top MAN1B1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,016.67
Details
HOST_HEK293 Human His tag   500 μg Log in to see 5 Days
$1,732.50
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

MAN1B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1) Interaction Partners

Human Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1) interaction partners

  1. Data show that HIV-1 env (show ERVW-1 Proteins) protein interacts with alpha-mannosidases ERManI (MAN1B1) and initiates endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway degradation process.

  2. The properties of ERMAN1 enable rapid selection of endoplasmic reticulum-associated degradation substrates in the endoplasmic reticulum.ERMAN1 digests mono-, di- and tri (show VANGL2 Proteins)-glucosylated N-glycans.

  3. we linked mutations in MAN1B1 to a Golgi glycosylation disorder. Additionally, our results support the recent findings on MAN1B1 localization

  4. MAN1B1 deficiency appeared to be a frequent cause in our cohort of patients with unsolved congenital disorder of glycosylation type II.

  5. A novel post-transcriptional regulatory mechanism for ERManI via miR (show MLXIP Proteins)-125b and this molecule contributes to the regulation of carcinogenesis in hepatocellular carcinoma.

  6. ERManI and gamma-COP (show COPg1 Proteins) contribute to a golgi-based quality control module that facilitates the retrieval of captured ERAD substrates back to the endoplasmic reticulum.

  7. A homozygous nonsense mutation in MAN1B1 segregated with nonsyndromic autosomal-recessive intellectual disability and additional dysmorphic features.

  8. ER processing alpha1,2-mannosidase (ER ManI) has a role in ER-associated degradation of misfolded proteins

  9. Modification by endoplasmic reticulum mannosidase I (ERManI) contributes to the preferential selection of the misfolded AAT (show SERPINA1A Proteins) monomer for proteasomal degradation.

  10. overexpression of Golgi alpha1,2-mannosidase IA, IB, and IC also accelerates ERAD of terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose trimming from the N-glycans on NHK in 293 cells

MAN1B1 Protein Profile

Protein Summary

This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11.

Gene names and symbols associated with MAN1B1

  • mannosidase, alpha, class 1B, member 1 (MAN1B1)
  • mannosidase, alpha, class 1B, member 1 (man1b1)
  • mannosidase, alpha, class 1B, member 1 (Man1b1)
  • E430019H13Rik protein
  • ERMan1 protein
  • Gm108 protein
  • MAN1B1 protein
  • MANA-ER protein
  • MRT15 protein
  • RGD1563595 protein

Protein level used designations for MAN1B1

mannosidase, alpha, class 1B, member 1 , alpha 1,2-mannosidase , ER alpha 1,2-mannosidase , Man9GlcNAc2-specific processing alpha-mannosidase , endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase , endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1 , ER alpha-1,2-mannosidase , ER mannosidase 1 , man9GlcNAc2-specific-processing alpha-mannosidase

GENE ID SPECIES
417296 Gallus gallus
447291 Xenopus laevis
473099 Pan troglodytes
480667 Canis lupus familiaris
100145194 Xenopus (Silurana) tropicalis
11253 Homo sapiens
227619 Mus musculus
499751 Rattus norvegicus
Selected quality suppliers for MAN1B1 Proteins (MAN1B1)
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