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anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Antibodies

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping MMP14 Proteins (26) and MMP14 Kits (24) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MMP14 4323 P50281
MMP14 17387 P53690
MMP14 81707 Q10739
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Top anti-MMP14 Antibodies at antibodies-online.com

Showing 10 out of 245 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, treated with etoposide 25uM 1h, using MMP14 (Cleaved-Tyr112) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB The anti-MMP14 N-term Antibody (ABIN390138) is used in Western blot to detect MMP14 in A375 lysate. Western blot analysis of MMP14 (arrow) using rabbit polyclonal MMP14 Antibody (N-term) (ABIN390138). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the MMP14 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB MMP14 Antibody (C-term) (ABIN1881546) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the MMP14 antibody detected the MMP14 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse PE FACS Detection of MMP-14/MT1-MMP in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 6 to 7 Days
$393.75
Details
Human Mouse Alexa Fluor 488 FACS Detection of MMP-14/MT1-MMP in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP Alexa Fluor 488-conjugated Monoclonal Antibody. 100 Tests Log in to see 6 to 7 Days
$413.44
Details
Human Mouse Un-conjugated IF, WB MMP14 Monoclonal Antibody (C-term)  western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the MMP14 antibody detected the MMP14 protein (arrow).(8ug/ml) Confocal immunofluorescent analysis of MMP14 Antibody (C-term)  with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, IHC, IP, WB Detection of MMP-14/MT1-MMP in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human MMP-14/MT1-MMP Monoclonal Antibody. 100 μg Log in to see 6 to 7 Days
$367.50
Details
Human Rabbit Un-conjugated WB Anti- MMP14 Picoband antibody, Western blotting All lanes: Anti MMP14  at 0.5ug/ml Lane 1: Human Placenta Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: U87 Whole Cell Lysate at 40ug Predicted bind size: 55KD Observed bind size: 55KD 100 μg Log in to see 4 to 6 Days
$240.00
Details

MMP14 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MMP14 Antibodies

  1. Human Monoclonal MMP14 Primary Antibody for FACS, IHC - ABIN4899219 : Mierke, Bretz, Altevogt: Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion. in The Journal of biological chemistry 2011 (PubMed)
    Show all 4 references for ABIN4899219

  2. Human Polyclonal MMP14 Primary Antibody for FACS, IHC (p) - ABIN390138 : Will, Hinzmann: cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. in European journal of biochemistry / FEBS 1995 (PubMed)
    Show all 4 references for ABIN390138

  3. Human Polyclonal MMP14 Primary Antibody for EIA, IHC (p) - ABIN358687 : Takino, Sato, Yamamoto, Seiki: Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain. in Gene 1995 (PubMed)
    Show all 2 references for ABIN358687

  4. Human Polyclonal MMP14 Primary Antibody for ELISA, WB - ABIN1536142 : Sato, Takino, Okada, Cao, Shinagawa, Yamamoto, Seiki: A matrix metalloproteinase expressed on the surface of invasive tumour cells. in Nature 1994 (PubMed)
    Show all 2 references for ABIN1536142

  5. Human Monoclonal MMP14 Primary Antibody for FACS - ABIN4895756 : Loskutov, Kozyulina, Kozyreva, Ice, Jones, Roston, Smolkin, Ivanov, Wysolmerski, Pugacheva: NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. in Oncogene 2015 (PubMed)

  6. Human Polyclonal MMP14 Primary Antibody for WB - ABIN1881546 : Sakr, Takino, Domoto, Nakano, Wong, Sasaki, Nakanuma, Sato: GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. in Cancer science 2010 (PubMed)

  7. Human Monoclonal MMP14 Primary Antibody for FACS - ABIN4895758 : Sathyamoorthy, Tezera, Walker, Brilha, Saraiva, Mauri, Wilkinson, Friedland, Elkington: Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

More Antibodies against MMP14 Interaction Partners

Human Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. Studies demonstrate that the interaction Bst-2 (show BST2 Antibodies) and MT1-MMP, actually happens and the cytoplasmic tails, both the N-terminal domain of Bst-2 (show BST2 Antibodies) and the C-terminal domain of MT1-MMP, play crucial roles in the interaction. The interaction between Bst-2 (show BST2 Antibodies) and MT1-MMP is important in MT1-MMP regulating the tetherin (show BST2 Antibodies) activity of Bst-2 (show BST2 Antibodies) and also in Bst-2 (show BST2 Antibodies) regulating the activity of the MT1 (show MT1A Antibodies)-MP/proMMP2/MMP2 (show MMP2 Antibodies) pathway.

  2. The subgroup of patients with double expression of MMP-14 and CD44 (show CD44 Antibodies) had a poor prognosis despite complete debulking. Serous subtype in advanced-stage patients and CD44 (show CD44 Antibodies) expression were found to be correlated with vimentin (show VIM Antibodies) expression, and CD44 (show CD44 Antibodies) expression was found to be significantly correlated with complete debulking

  3. Akt (show AKT1 Antibodies) level was reduced in preeclamptic placentas relative to preterm control. Inhibition of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) resulted in significantly elevated soluble endoglin (show ENG Antibodies) release from endothelial cells, had no effect on MMP14 mRNA expression but resulted in significantly reduced TIMP3 (show TIMP3 Antibodies). In contrast inhibiting PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) in placental explants or primary trophoblast did not change soluble endoglin (show ENG Antibodies) release.

  4. possible involvement of membrane-type 1 matrix metalloproteinase processing of erythropoietin (show EPO Antibodies)-producing hepatocellular receptor-2in invasiveness of cutaneous cutaneous squamous cell carcinoma

  5. Findings suggest that regulation of cellular trafficking and microtubule-mediated localization of MT1-MMP by mDia1 is likely important in breast cancer invasion through the expression of cancer stem cell genes.

  6. Gelatin zymography and WB experiment showed that hHK-1 (show HOOK1 Antibodies) enhanced the levels of MMP-2 (show MMP2 Antibodies) and MMP-14; inhibition of these two MMPs blocked hHK-1 (show HOOK1 Antibodies)-induced cell migration.

  7. The results suggest that MT1-MMP promotes esophageal squamous cell carcinoma invasion and metastasis.

  8. Report design of PEGylated peptide probes conjugated with (18)F-labeled BODIPY to be used as a hybrid PET/optical imaging agent and for non-invasive monitoring of MT1-MMP activity in cancers.

  9. Rab8 (show RAB8A Antibodies) can induce Rac1- and Tiam1 (show TIAM1 Antibodies)-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP and calpain, and Rho-GTPase (show RACGAP1 Antibodies)-dependent mechanisms

  10. Downregulation of miR (show MLXIP Antibodies)-193a-3p promoted loss of type II collagen (show COL2A1 Antibodies) by directly targeting MMP14 in IDD (show COL9A3 Antibodies). miR (show MLXIP Antibodies)-193a-3p inhibited IDD (show COL9A3 Antibodies) in vitro and in vivo. miR (show MLXIP Antibodies)-193a-3p may be a promising candidate for prevention of degenerative disc disease.

Mouse (Murine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. MT1-MMP directly cleaves LYVE-1 (show LYVE1 Antibodies) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 Antibodies)-mediated lymphangiogenic responses and restrains the production of VEGF-C (show VEGFC Antibodies).

  2. The authors propose a model for cell-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular bridge tethering collagen fibrils to the plasma membrane of fibripositors.

  3. We demonstrate that MMP-14-mediated signaling in fetal hepatic progenitor cells promotes biliary luminal formation around the portal vein and negatively controls the maturation of hepatocytes.

  4. Results show a reciprocal association between levels of heparanase (show HPSE Antibodies) and MMP14, a membrane-bound MMP, shedding light on how branching occurs within developing mammary glands.

  5. MT1-MMP proteolytic activity is required for maintaining cell integrity, loss of MT1-MMP causes cell senescence and nuclear defects.

  6. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 (show TIMP1 Antibodies) and TIMP2 (show TIMP2 Antibodies) correlates negatively with the invasive potential of cells.

  7. Angiotensin II suppresses RECK (show RECK Antibodies), but induces matrix metalloproteinases both in vivo and in vitro.

  8. Active MT1-MMP promotes Notch1 (show NOTCH1 Antibodies) cleavage independently of ADAM10 (show ADAM10 Antibodies) or -17.

  9. LV mass was similar among WT, MT1-MMP overexpression, and MT1-MMP reduced expression after PO, significant differences in LV function.

  10. In the kidneys of Sirt1 (show SIRT1 Antibodies)(endo-/-) mice, impaired angiogenesis, reduced matrilytic activity, and retention of the profibrotic cleavage substrates tissue transglutaminase (show TGM2 Antibodies) and endoglin (show ENG Antibodies) accompanied MMP-14 suppression.

Cow (Bovine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. results suggest that ET-1 (show EDN1 Antibodies)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (show NOX1 Antibodies)-PKCalpha (show PKCa Antibodies)-p(38)MAPK (show MAPK1 Antibodies) and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 (show TIMP2 Antibodies) expression in the cells

  2. Data indicate the involvement of PKC-alpha (show PKCa Antibodies) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP-dependent and -independent pathway.

  3. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (show MMP2 Antibodies); MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

  4. MMP-14, MMP-2 (show MMP2 Antibodies) and TIMP-2 (show TIMP2 Antibodies) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  5. Results describe distinct changes in expression of MMP2 (show MMP2 Antibodies), MMP14, and the metallopeptidase (show ECEL1 Antibodies) inhibitor TIMP2 (show TIMP2 Antibodies) between different phases of the estrous cycle indicating an endocrine regulation.

  6. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 (show MMP2 Antibodies) and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.

  7. MT1-MMP seems to act by inducing tissue remodeling in cartilage

  8. sphingosine 1-phosphate is the predominant serum factor essential for MT1-MMP-dependent migration and morphogenic differentiation of vascular endothelial cells

Rabbit Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. MT1-MMP plays a crucial role in RAGE (show AGER Antibodies)-activated NADPH oxidase (show NOX1 Antibodies)-dependent signaling pathways.

  2. MMP-1 (show MMP1 Antibodies) was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation.

Pig (Porcine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) interaction partners

  1. Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion.

  2. A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling.

  3. PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 (show MMP2 Antibodies) as critical events in neointimal hyperplasia after vascular injury.

  4. Induction of endogenous MMP-14 gene and coexpression of SAF-1 (show MAZ Antibodies) & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 (show MAZ Antibodies) as a key regulator of MMP-14 gene induction in macrophage cells.

  5. In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion.

MMP14 Antigen Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Gene names and symbols associated with MMP14

  • matrix metallopeptidase 14 (membrane-inserted) (mmp14) antibody
  • matrix metallopeptidase 14 (membrane-inserted) (MMP14) antibody
  • matrix metallopeptidase 14 (membrane-inserted) (Mmp14) antibody
  • AI325305 antibody
  • MMP-14 antibody
  • MMP-X1 antibody
  • MMP1 antibody
  • MT-MMP antibody
  • MT-MMP-1 antibody
  • MT-MMP 1 antibody
  • Mt1-mmp antibody
  • MT1MMP antibody
  • MTMMP1 antibody
  • sabe antibody

Protein level used designations for MMP14

matric metalloproteinase 14 , matrix metalloproteinase-14 , membrane type 1 metalloprotease , membrane-type-1 matrix metalloproteinase , MMP-14 , MMP-X1 , MT-MMP 1 , MT1MMP , MTMMP1 , Membrane type 1-MMP , matrix metalloproteinase 14 (membrane-inserted) , membrane-type matrix metalloproteinase 1 , type 1 matrix metalloprotease 14 , matrix metalloproteinase 14 membrane-inserted , matrix metalloproteinase 14, membrane-inserted , membrane type 1-matrix metalloproteinase , MT1-MMP , matrix metalloproteinase 14 preproprotein , matrix metallopeptidase 1 (interstitial collagenase) , matrix metalloproteinase 14 , membrane type 1 metalloproteinase , membrane-type 1 matrix metalloproteinase , membrane type-1 metalloproteinase

GENE ID SPECIES
594950 Xenopus (Silurana) tropicalis
4323 Homo sapiens
17387 Mus musculus
81707 Rattus norvegicus
281915 Bos taurus
100009598 Oryctolagus cuniculus
397471 Sus scrofa
443116 Ovis aries
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