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MMP19 encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP19 Kits (14) and MMP19 Proteins (7) and many more products for this protein.
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Human Polyclonal MMP19 Primary Antibody for EIA, IHC (p) - ABIN358691
Sadowski, Dietrich, Koschinsky, Sedlacek et al.: Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding ... in Molecular biology of the cell 2003
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transcriptional target (show ESR2 Antibodies) of ligand-bound activated (show ESR2 Antibodies) estrogen receptor beta (show PSG1 Antibodies)acting on a specificity protein-1 binding site
the downregulation of MMP19 following respiratory syncytial virus infection may be associated with the development of airway hyperresponsiveness.
Loss of NDRG2 (show NDRG2 Antibodies) induced the expression of matrix metalloproteinase-19 (MMP-19), which regulated the expression of Slug (show SNAI2 Antibodies) at the transcriptional level in the epithelial-mesenchymal transition of gallbladder carcinoma cells.
Triplication of an enhancer may lead to overexpression of MMP19 in the optic nerve that causes cavitary optic disc anomaly.
the intima+media of IPAH vessels, collagens (COL4A5 (show COL4a5 Antibodies), COL14A1 (show COL14A1 Antibodies), and COL18A1 (show COL18A1 Antibodies)), matrix metalloproteinase (show MMP20 Antibodies) (MMP) 19, and a disintegrin and metalloprotease (show ADAM8 Antibodies) (ADAM) 33 (show ADAM33 Antibodies) were higher expressed, whereas MMP10 (show MMP10 Antibodies), ADAM17 (show ADAM17 Antibodies), TIMP1 (show TIMP1 Antibodies), and TIMP3 (show TIMP3 Antibodies) were less abundant.
The expression of MMP-19 in the main forms of gastrointestinal diseases, was analysed.
Matrix metalloproteinase-19 in lung epithelial cells stimulates proliferation and cell migration. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201310-1903OC
ASNS (show ASNS Antibodies) and MMP19, along with eIF3a (show EIF6 Antibodies), are the sensitivity factors for cisplatin treatment and may serve as potential candidate molecular markers for predicting cisplatin sensitivity of advanced nasopharyngeal carcinoma.
These findings indicated for the first time that the co-expression of MMP-14 (show MMP14 Antibodies) and MMP-19 is significantly correlated with prognosis in glioma patients
Up-regulation of (show PTGS2 Antibodies)matrix metalloproteinase-19 (MMP19) induced by lung injury may play a protective role in the development of fibrosis through the induction of prostaglandin-endoperoxide synthase 2 (PTGS2).
Estrogen receptor beta (show ESR2 Antibodies) target gene, where ERbeta (show ESR2 Antibodies) requires a specific Sp1 (show SP1 Antibodies) site on the MMP-19 promoter to mediate ligand dependent transcription
These findings suggest that, in lung fibroblasts, MMP-19 has strong regulatory effects on the synthesis of key ECM (show MMRN1 Antibodies) components, on fibroblast to myofibroblast differentiation, and in migration and proliferation.
MMP-19-deficiency improves the development of hepatic fibrosis through the diminished replacement of physiological extracellular matrix with fibrotic deposits in the beginning of the injury
In WT mice, PTGS2 (show PTGS2 Antibodies) was significantly increased in bronchoalveolar lavage and lung tissues after bleomycin-induced fibrosis, but not in Mmp19-/- mice. Inhibition of Mmp-19 by siRNA resulted in inhibition of Ptgs2 (show PTGS2 Antibodies) at mRNA and protein levels.
An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 (show ETS1 Antibodies) as well as reduced host immune response in angiogenesis and migration.
Matrix metalloproteinase-19 deficiency promotes tenascin-C (show TNC Antibodies) accumulation and allergen-induced airway inflammation.
Mmp19-null mice develop a diet-induced obesity due to adipocyte hypertrophy and exhibit decreased susceptibility to skin tumors induced by chemical carcinogens.
Based on the phenotype of MMP19-deficient mice we propose that MMP19 is an important factor in cutaneous immune responses and influences the development of T cells
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene.
matrix metallopeptidase 19
, matrix metalloproteinase-18
, matrix metalloproteinase RASI
, matrix metalloproteinase-19
, matrix metalloproteinase-beta19
, matrix metalloproteinase 19